ID G1QMZ9_NOMLE Unreviewed; 712 AA.
AC G1QMZ9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DDX4 {ECO:0000313|Ensembl:ENSNLEP00000002315.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002315.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002315.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002315.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|RuleBase:RU000492}.
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DR EMBL; ADFV01030683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01030684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QMZ9; -.
DR STRING; 61853.ENSNLEP00000002315; -.
DR Ensembl; ENSNLET00000002441.2; ENSNLEP00000002315.2; ENSNLEG00000001662.3.
DR eggNOG; KOG0335; Eukaryota.
DR GeneTree; ENSGT00940000157507; -.
DR HOGENOM; CLU_003041_16_3_1; -.
DR InParanoid; G1QMZ9; -.
DR OMA; NRXSNND; -.
DR TreeFam; TF300364; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR CDD; cd18052; DEADc_DDX4; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF143; ATP-DEPENDENT RNA HELICASE DDX4-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 276..304
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 307..490
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 518..663
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 28..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 276..304
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 68..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 78078 MW; A5B4271649E6C7E8 CRC64;
MADEDWEAEI NPHMSSYVPI FEKDRYSSGE NADNFNRAPA SSSEMDDGPS RRDHFMKSGF
ASGRNFGNRD AGESNKQDNT STMGGFGVGK SFGNRGFSNS KFEDGDSSGF WREFSNDCED
NPTRNRGFSK RGGYRDGNNS EASGPSRRGF GLGSPNNDLD PDECMQRTGG LFGYRRSALR
LSGYGDTSQS RSGSGSERGG YKGLNEEVIT GSGKSNEKAE GGESSDTQGP KVTYIPPPPP
EDEDSIFAHY QTGINFDKYD TILVEVSGHD APPAILTFEE ADLCQTLNNN IAKAGYTKLT
PVQKYSIPII LAGRDLMACA QTGSGKTAAF LLPILAHMMR DGITASRFKE LQEPECIIVA
PTRELVNQIY LEARKFSFGT CVRAVVIYGG TQLGHSIRQI VQGCNILCAT PGRLMDIIGK
EKIGLKQIKY LVLDEADRML DMGFGPEMKK LISCPGMPSK EQRQTLMFSA TFPEEIQRLA
AEFLKSNYLF VAVGQVGGAC RDVQQTVLQV GQFSKREKLV EILRNIGDER TMVFVETKKK
ADFIATFLCQ EKISTTSIHG DREQREREQA LGDFRCGKCP VLVATSVAAR GLDIENVQHV
INFDLPSTID EYVHRIGRTG RCGNTGRAIS FFDLESDNQL AQPLVKVLTD AQQDVPAWLE
EIAFSTYIPG FSGSTRGSVF ASVDTRKGKS TLNTAGFSSS QAPNPVDDES WD
//
