ID G1QN90_NOMLE Unreviewed; 460 AA.
AC G1QN90;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Interferon regulatory factor 6 {ECO:0000313|Ensembl:ENSNLEP00000002406.2};
GN Name=IRF6 {ECO:0000313|Ensembl:ENSNLEP00000002406.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002406.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002406.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002406.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01074529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QN90; -.
DR Ensembl; ENSNLET00000002535.2; ENSNLEP00000002406.2; ENSNLEG00000001962.2.
DR eggNOG; ENOG502QRNT; Eukaryota.
DR GeneTree; ENSGT00940000157451; -.
DR HOGENOM; CLU_031544_0_1_1; -.
DR TreeFam; TF328512; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF9; INTERFERON REGULATORY FACTOR 6; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 7..115
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 121..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 52443 MW; 855138534C1EEBD4 CRC64;
MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ EEENTIFKAW
AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT KEVPMNPVKI YQVCDIPQPQ
GSIINPGSTG SAPWDEKDND VDEEDEEDEL DQSQHHVPIQ DTFPFLNING SPMAPASVGN
CSAVWPKTEP LEMEVPQAPI QPFYSSPELW ISSLPMTDLD IKFQYRGKEY GQTMTVSNPQ
GCRLFYGDLG PMPDQEELFG PVSLEQVKFP GPEHITNEKQ KLFTSKLLDV MDRGLILEVS
GHAIYAIRLC QCKVYWSGPC APSLVAPNLI ERQKKVKLFC LETFLSDLIA HQKGQIEKQP
PFEIYLCFGE EWPDGKPLER KLILVQVIPV VARMIYEMFS GDFTRSFDSG SVRLQISTPD
IKDNIVAQLK QLYRILQTQE SWQPMQPTPS MQLPPALPPQ
//
