ID G1QNE6_NOMLE Unreviewed; 1009 AA.
AC G1QNE6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DENN domain containing 2A {ECO:0000313|Ensembl:ENSNLEP00000002462.2};
GN Name=DENND2A {ECO:0000313|Ensembl:ENSNLEP00000002462.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002462.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002462.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002462.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01061972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01061981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QNE6; -.
DR STRING; 61853.ENSNLEP00000002462; -.
DR Ensembl; ENSNLET00000002592.2; ENSNLEP00000002462.2; ENSNLEG00000002026.3.
DR eggNOG; KOG3569; Eukaryota.
DR GeneTree; ENSGT00950000182931; -.
DR HOGENOM; CLU_008960_1_1_1; -.
DR InParanoid; G1QNE6; -.
DR OMA; CPAYVPL; -.
DR TreeFam; TF320336; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF3; DENN DOMAIN-CONTAINING PROTEIN 2A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 566..969
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 20..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 114055 MW; 3BBE9CAD803427E9 CRC64;
MDMFSLDMII SDPAAEASRA GKKQLRGVQN PCPSARAGPR HKSLNIKDKI SEWEGKKEVP
APAPSRRADV QEDYLPSCMV ERRSSDGVRT QVTEAKNGMR PGTERTGKER NKGAVNVGGQ
DPGPGQDLSQ PEREVDPSWG RGREPRLGKL RFQNDHLSVL KQVKKLEQAL KDGSAGLDPQ
LPGTCYSPHC PPDKAEAGPT LPENLGGGSG SEVSQRVHPS DLEGREPALE VVEDRKGSCR
RPWDRSLENV YRGSEGSPTK PFINPLPKPR RTFKHAGEGD KDGKPGISFR KEKRNLPPLP
SLPPPPLPSS PPPSSVNRRL WTGRQKSSAD HRKSYEFEDL LQSSSESSRV DWYAQTKLGL
TRTLSEENVY EDILGKRPQK NFQKEEIENL RKGRCLAKQL ELHLCPGCWR WAPAKQSLSK
PAFFRQNSER RNFKLLDTRK LSRDGTGSPS KISPPSTPSS PDDIFFNLGD PQNGRKKRKI
PKLVLRINAI YEVRRGKKRV KRLSQSTESN SGKVTDENSE SDSDTEEKLK AHSQRLVNVK
SRLKQAPRYP SLARELIEYQ ERQLFEYFVV VSLHKKQAGA AYVPELTQQF PLKLERSFKF
MREAEDQLKA IPQFCFPDAK DWVPVQQFTS ETFSFVLTGE DGSRRFGYCR RLLPGGKGKR
LPEVYCIVSR LGCFSLFSKI LDEVEKRRGI SPALVQPLMR SVMEAPFPAL GKTILVKNFL
PGSGTEVIEL CRPLDSRLEH VDFESLFSSL SVRHLVCVFA SLLLERRVIF IADKLSTLSK
CCHAMVALIY PFTWQHTYIP VLPPAMVDIV CSPTPFLIGL LSSSLPLLRE LPLEEVLVVD
LVNSRFLRQM DDEDSILPRK LQVALEHILE QRNELACEQD EGPLDGRHGP ESSPLNEVVS
EAFVRFFVET VGHYSLFLTS GEREERTLQR EAFRKAVSSK SLRHFLEVFM ETQMFRGFIQ
ERELRRQDAK GLFEVRAQEY LETLPSGEHS GVNKFLKGLG NKMKFLHKK
//
