ID G1QNU7_NOMLE Unreviewed; 619 AA.
AC G1QNU7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN Name=SYT14 {ECO:0000313|Ensembl:ENSNLEP00000002613.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002613.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002613.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002613.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996}.
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DR EMBL; ADFV01074536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01074545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QNU7; -.
DR Ensembl; ENSNLET00000002751.2; ENSNLEP00000002613.2; ENSNLEG00000002083.3.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000159420; -.
DR HOGENOM; CLU_023008_6_1_1; -.
DR OMA; MTFLFWY; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd08389; C2A_Synaptotagmin-14_16; 1.
DR CDD; cd08408; C2B_Synaptotagmin-14_16; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR043541; SYT14/14L/16.
DR PANTHER; PTHR46129; SYNAPTOTAGMIN 14, ISOFORM D; 1.
DR PANTHER; PTHR46129:SF3; SYNAPTOTAGMIN-14-RELATED; 1.
DR Pfam; PF00168; C2; 2.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 305..424
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 460..614
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 202..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 69248 MW; 1D9DBC2BE003D666 CRC64;
VASTSWRLKV EREPVEYMNL SVLEKIGSYS VARLEYSGAI LAHCNLRLLD SNDSSASASR
VAGTTVSPEA VGFLSAVGVF IILMLLLFLY INKKFCFENV GGFPDLGSEY STRKNSQDKI
YNSYMDKDEH GSSSESEDEA LGKYHEALSR THNSRLPLAD SRQKNYAWET RQKYSPLSAE
YDGYSSEASI DEGNCIQRMR RTPPLDELQP PPYQDDSGSP HLSCTPSEIG DSKCEFSHCS
NSPRCSYNKC PSEGSTGHEI ESFHNKGYEE DVPSDSTAVL SPEDMSAQGS SSQLPKPFDP
EPEAKYGTLD VTFDYDSQEQ KLLVTVTAVT DIPTYNRTGG NSWQVHLVLL PIKKQRAKTS
IQRGPCPVFT ETFKFNHVES EMIGNYAVRF RLYGVHRMKK EKIVGEKIFY LTKLNLQGKM
SLPVILEPSY NHSGCDSQMS VSEMSCSEST SSCQSLEHGS VPEILIGLLY NATTGRLSAE
VIKGSHFKNL AANRPPNGLF CCLKHLIGGQ VYIIRDTYVK LTLLNSMGQE MSKCKTSIRR
GQPNPVYKET FVFQVALFQL SDVTLILSVY NKRSMKRKEM IGWISLGLNS SGEEELNHWT
EMKESKGQQV CRWHALLES
//
