ID G1QP27_NOMLE Unreviewed; 460 AA.
AC G1QP27;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Keratin, type I cytoskeletal 27 {ECO:0000256|ARBA:ARBA00040314};
DE AltName: Full=Cytokeratin-27 {ECO:0000256|ARBA:ARBA00041720};
DE AltName: Full=Keratin-27 {ECO:0000256|ARBA:ARBA00042484};
DE AltName: Full=Type I inner root sheath-specific keratin-K25irs3 {ECO:0000256|ARBA:ARBA00043216};
GN Name=KRT27 {ECO:0000313|Ensembl:ENSNLEP00000002693.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002693.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002693.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002693.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential for the proper assembly of type I and type II
CC keratin protein complexes and formation of keratin intermediate
CC filaments in the inner root sheath (irs).
CC {ECO:0000256|ARBA:ARBA00037136}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with KRT6A to form filaments.
CC {ECO:0000256|ARBA:ARBA00038833}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; ADFV01106170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003278326.1; XM_003278278.1.
DR AlphaFoldDB; G1QP27; -.
DR STRING; 61853.ENSNLEP00000002693; -.
DR Ensembl; ENSNLET00000002837.2; ENSNLEP00000002693.1; ENSNLEG00000002229.2.
DR GeneID; 100589012; -.
DR KEGG; nle:100589012; -.
DR CTD; 342574; -.
DR GeneTree; ENSGT00940000161982; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; G1QP27; -.
DR OMA; SRVHTME; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF120; KERATIN, TYPE I CYTOSKELETAL 27; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 85..400
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 435..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 89..123
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 199..233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 258..364
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 435..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50011 MW; 931A5CB1D6AE1FEB CRC64;
MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCIVPG IGSGFSSCAF GGSSSAGGYG
GGLGGGSASC AAFTGNEHGL LSGNEKVTMQ NLNDRLASYL ENVRTLEEAN ADLEQKIKGW
YEKFGPGSCR GLDHDYSRYF PIIDELKNQI ISATTSNAHV VLQNDNARLT ADDFRLKFEN
ELALHQSVEA DINGLRRVLD ELTLCRTDLE IQLETLSEEL AYLKKNHEEE MKALQCAAGG
NVNVEMNAAP GVDLTVLLNN MRAEYEALAE QNRRDAEAWF NEKSASLQQQ ISDDAGATTS
ARNELTEMKR TLQTLEIELQ SLLATKHSLE CSLTETESNY CAQLAQIQAQ IGALEEQLHQ
VRTETEGQKL EYEQLLDVKV HLEKEIETYC LLIDGEDGSC SKSKGYGGPG NQTKDSSKTT
IVKTVVEEID PRGKVLSSRV HTMKEKSTKV NNKNEQRVPS
//
