ID G1QP70_NOMLE Unreviewed; 310 AA.
AC G1QP70;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
GN Name=QPCTL {ECO:0000313|Ensembl:ENSNLEP00000002736.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002736.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002736.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002736.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01102019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QP70; -.
DR STRING; 61853.ENSNLEP00000002736; -.
DR Ensembl; ENSNLET00000002882.3; ENSNLEP00000002736.2; ENSNLEG00000002287.3.
DR eggNOG; KOG3946; Eukaryota.
DR GeneTree; ENSGT00390000003107; -.
DR HOGENOM; CLU_045003_3_0_1; -.
DR InParanoid; G1QP70; -.
DR OMA; HYETNYP; -.
DR TreeFam; TF315071; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF3; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-LIKE PROTEIN; 1.
DR Pfam; PF04389; Peptidase_M28; 2.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..217
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 225..302
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 310 AA; 34721 MW; 2853EE9D038603F7 CRC64;
MRSGGRGRPR LRLGERGLME PLLPRKRRLL PRVRLLPLLL ALAVGSAFYT IWSGWHRRTE
ELPLGRELRV PLIGSLPEAR LRRVVGQVDP QRLWSTYLRP CWLCEPRAFL EATLRSLTAG
WHVELDPFTA STPLGPVDFG NVVATLDPRA ARHLTLACHY DSKLFPPGST PFVGATDSAV
PCALLLELAQ ALDLELSRAK EQAAPVTLQL LFLYGDEAQA EESLKRLHRL NLLQSHPQEV
MYFQPGEPFG SVEDDHIPFL RRGVPVLHLI STPFPAVWHT PADTEANLHP PTVHNLSRIL
AVFLAEYLGL
//
