ID G1QPH3_NOMLE Unreviewed; 469 AA.
AC G1QPH3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Macrophage scavenger receptor 1 {ECO:0000313|Ensembl:ENSNLEP00000002839.1};
GN Name=MSR1 {ECO:0000313|Ensembl:ENSNLEP00000002839.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002839.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002839.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
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DR EMBL; ADFV01171361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01171362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01171363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01171364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003256747.2; XM_003256699.2.
DR AlphaFoldDB; G1QPH3; -.
DR STRING; 61853.ENSNLEP00000002839; -.
DR Ensembl; ENSNLET00000002987.2; ENSNLEP00000002839.1; ENSNLEG00000002324.3.
DR eggNOG; ENOG502QUW0; Eukaryota.
DR GeneTree; ENSGT00950000183074; -.
DR HOGENOM; CLU_041152_2_0_1; -.
DR InParanoid; G1QPH3; -.
DR OMA; DDHWEIR; -.
DR TreeFam; TF330855; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0097242; P:amyloid-beta clearance; IEA:Ensembl.
DR GO; GO:0030301; P:cholesterol transport; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0042953; P:lipoprotein transport; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006911; P:phagocytosis, engulfment; IEA:Ensembl.
DR GO; GO:0034381; P:plasma lipoprotein particle clearance; IEA:Ensembl.
DR GO; GO:0010886; P:positive regulation of cholesterol storage; IEA:Ensembl.
DR GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR003543; SR-AI/II.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071:SF5; NEUROTRYPSIN; 1.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 1.
DR Pfam; PF03523; Macscav_rec; 1.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR01408; MACSCAVRCPTR.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 368..468
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 285..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 198..250
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 393..457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 406..467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 437..447
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 469 AA; 51595 MW; 0285B06ED91D0722 CRC64;
MCYLSAIISI SLLNRKSSME QWDRFHNQQE ETDSCSESVK FDARSMTALL PPNPKISASL
QEKLKSFKAA LIVLYLLVFA VLIPLTGIVA AQLLKWETKN CSVGSTHAND ITQSLTGKGN
DSEEEMRFQE VFMEHMSNME KRIQHISGME ANLIDTEHFQ NFSMTADQRF NGILLQLSTL
FSSVQGHGNA IDEISKSLIS LNTTLLDLQL NIENLNGKIQ ENTFKQQEEI SKLEERVYNV
SAEIMAMKEE QVHLEQEIKG EVKVLNNITN DLRLKDWEHS QTLRNITLIQ GPPGPPGEKG
DRGPTGESGP RGFPGPIGPP GLKGDRGAIG FPGSRGLPGY AGRPGNSGPK GQKGEKGSGN
TLTPFQKVRL VGGSGPHEGR VEILHSGQWG TICDDRWEVR VGQVVCRSLG YPGVQAVHKA
AHFGQGTGPI WLNEVFCFGR ESSIEECKIR KWGTRACSHS EDAGVTCTL
//
