ID G1QQJ0_NOMLE Unreviewed; 383 AA.
AC G1QQJ0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=NIPA like domain containing 2 {ECO:0000313|Ensembl:ENSNLEP00000003208.1};
GN Name=NIPAL2 {ECO:0000313|Ensembl:ENSNLEP00000003208.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003208.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003208.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA family.
CC {ECO:0000256|ARBA:ARBA00007230}.
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DR EMBL; ADFV01167442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01167443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01167444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01167445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01167446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01167447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01167448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003256088.1; XM_003256040.2.
DR AlphaFoldDB; G1QQJ0; -.
DR STRING; 61853.ENSNLEP00000003208; -.
DR Ensembl; ENSNLET00000003369.3; ENSNLEP00000003208.1; ENSNLEG00000002626.3.
DR GeneID; 100586196; -.
DR KEGG; nle:100586196; -.
DR CTD; 79815; -.
DR eggNOG; KOG2922; Eukaryota.
DR GeneTree; ENSGT00940000159321; -.
DR HOGENOM; CLU_012349_2_0_1; -.
DR InParanoid; G1QQJ0; -.
DR OMA; HLQQSFI; -.
DR TreeFam; TF313214; -.
DR Proteomes; UP000001073; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF16; NIPA-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 350..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 42051 MW; B1D05BC395E96277 CRC64;
MAALAPAGSG DAASAALDEL SLNFTYGAPG AGNGSLSGDW YRRNQIHLFG VLLAILGNLV
ISISLNIQKY SHLQLAQQEH PRPYFKSVLW WGGVLLMAVG ETGNFAAYGF APITLIAPLG
CVSVTGSAII SVTFLKDNLR ASDLLGMTLA FAGTYLLVNF APNITQAISA RTVQYYLVGW
QFLIYVILEI LIFCILLYFY KRKGMKHMVI LLTLVAILAS LTVISVKAVS GMITFSMTDK
MQLTYPIFSI MFIIMIASCA FQVKFLNQAM KLYNTTTVVP VNHIFFTISA IIAGIIFYQE
FLGAAFLTVF IYLFGCFLSF LGVFLVTRNR EKEHLQESYI DFGNIPGKQT LDKIQPDSNS
LSYGTLPDGS DSTKSQDGEK KEV
//
