ID G1QR39_NOMLE Unreviewed; 716 AA.
AC G1QR39;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000003407.2};
GN Name=PRKD2 {ECO:0000313|Ensembl:ENSNLEP00000003407.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003407.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003407.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003407.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. PKD subfamily. {ECO:0000256|ARBA:ARBA00008582}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01102176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QR39; -.
DR STRING; 61853.ENSNLEP00000003407; -.
DR Ensembl; ENSNLET00000003574.3; ENSNLEP00000003407.2; ENSNLEG00000002792.3.
DR eggNOG; KOG4236; Eukaryota.
DR GeneTree; ENSGT00950000183024; -.
DR HOGENOM; CLU_009772_1_0_1; -.
DR InParanoid; G1QR39; -.
DR OMA; WVVHYSS; -.
DR TreeFam; TF314320; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004697; F:diacylglycerol-dependent serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:2000573; P:positive regulation of DNA biosynthetic process; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
DR GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0036211; P:protein modification process; IEA:UniProt.
DR CDD; cd20795; C1_PKD_rpt1; 1.
DR CDD; cd01239; PH_PKD; 1.
DR CDD; cd14082; STKc_PKD; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22968; PROTEIN KINASE C, MU; 1.
DR PANTHER; PTHR22968:SF12; SERINE_THREONINE-PROTEIN KINASE D2; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 138..188
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 271..383
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 425..690
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 454
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 716 AA; 78988 MW; 04A61ADFA88BDA22 CRC64;
MAATSSYPAG LPGSPGPGSP PPPGGLELQS PPPLLPQIPA PGSGVSFHIQ IGLTREFVLL
PAASELAHVK QLACSIVDQK FPECGFYGLY DKILLFKHDP TSANLLQLVR SAGDIQEGDL
VEVVLSASAT FEDFQIRPHA LTVHSYRAPA FCDHCGEMLF GLVRQGLKCD DCKFNCHKRC
ATRVPNDCLG EALINGDVPM EEATDFSEAD KSALMDESED SGVIPGSHSE NALHASEEEE
GEGGKAQSSL GYIPLMRVVQ SVRHTTRKSS TTLREGWVVH YSNKDTLRKR HYWRLDCKCI
TLFQNNTTNR YYKEIPLSEI LTVESAQNFS LVPPGTNPHC FEIVTANATY FVGEMPGGAP
GGPSGQGAEA ARGWETAIRQ ALMPVILQDA PSAPGHAPHR QASLSISVSN SQIQENVDIA
TVYQIFPDEV LGSGQFGVVY GGKHRKTGRD VAVKVIDKLR FPTKESQLRN EVSILQSLRH
PGIVNLECMF ETPEKVFVVM EKLHGDMLEM ILSSEKGRLP ERLTKFLITQ ILVALRHLHF
KNIVHCDLKP ENVLLASADP FPQVKLCDFG FARIIGEKSF RRSVVGTPAY LAPEVLLNQG
YNRSLDMWSV GVIMYVSLSG TFPFNEDEDI NDQIQNAAFM YPASPWSHIS AGGAWGAPTP
WAAIDLINNL LQVKMRKRYS VDKSLSHPWL QEYQTWLDLR ELEGKMGERY ITHESD
//
