ID G1QR98_NOMLE Unreviewed; 256 AA.
AC G1QR98;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU367011};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU367011};
GN Name=CA13 {ECO:0000313|Ensembl:ENSNLEP00000003466.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003466.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003466.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003466.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Reversible hydration of carbon dioxide.
CC {ECO:0000256|RuleBase:RU367011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718, ECO:0000256|RuleBase:RU367011}.
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DR EMBL; ADFV01050810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01050811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01050812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01050813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01050814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QR98; -.
DR Ensembl; ENSNLET00000003638.2; ENSNLEP00000003466.2; ENSNLEG00000002848.2.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000160659; -.
DR HOGENOM; CLU_039326_2_1_1; -.
DR TreeFam; TF316425; -.
DR Proteomes; UP000001073; Chromosome 16.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF81; CARBONIC ANHYDRASE 13; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU367011};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367011};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367011}.
FT DOMAIN 1..255
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 256 AA; 28781 MW; 3889C94C82348E32 CRC64;
RLSWLRGPIH WKEFFPIADG DQQSPIEIKT KEVIYDSSLR PLSIKYDPSS AKIISNSGHS
FNVDFDDTEN KSVLRGGPLT GSYRLRQFHL HWGSADDHGS EHIVDGVSYA AELHVVHWNS
DKYPSFVEAA HEPDGLAVLG VFLQIGEPNS QLQKITDILD SIKEKGKQTR FTNFDPLSLL
PPSWDYWTYP GSLTVPPLLE SVTWILLKQP INISSQQLAK FRSLLCTAEG EAAAFLVSNH
RPPQPLKGRK VRASFH
//
