ID G1QRG5_NOMLE Unreviewed; 358 AA.
AC G1QRG5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Guanine nucleotide-binding protein G(q) subunit alpha {ECO:0000256|ARBA:ARBA00040847};
DE AltName: Full=Guanine nucleotide-binding protein alpha-q {ECO:0000256|ARBA:ARBA00042116};
GN Name=GNAQ {ECO:0000313|Ensembl:ENSNLEP00000003533.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003533.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003533.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003533.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004126}.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR EMBL; ADFV01038189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01038198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QRG5; -.
DR STRING; 61853.ENSNLEP00000003533; -.
DR Ensembl; ENSNLET00000003706.3; ENSNLEP00000003533.3; ENSNLEG00000002860.3.
DR eggNOG; KOG0085; Eukaryota.
DR GeneTree; ENSGT00940000161347; -.
DR HOGENOM; CLU_014184_6_0_1; -.
DR InParanoid; G1QRG5; -.
DR OMA; EHQSEFY; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000654; Gprotein_alpha_Q.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF316; GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00442; GPROTEINAQ.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT COILED 7..34
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 358 AA; 42029 MW; 48A50B7D40F2D303 CRC64;
MTLESIMACC SEEAKEARRI NDEIERQLRR DKRDARRELK LLLLGTGESG KSTFIKQMRI
IHGSGYSDED KRGFTKLVYQ NIFTAMQAMI RAMDTLKIPY KYEHNKAHAQ LVREVDVEKV
SAFENPYVDA IKSLWNDPGI QECYDRRREY QLSDSTKYYL NDLDRVADPA YLPTQQDVLR
VRVPTTGIIE YPFDLQSVIF RMVDVGGQRS ERRKWIHCFE NVTSIMFLVA LSEYDQVLVE
SDNENRMEES KALFRTIITY PWFQNSSVIL FLNKKDLLEE KIMYSHLVDY FPEYDGPQRD
AQAAREFILK MFVDLNPDSD KIIYSHFTCA TDTENIRFVF AAVKDTILQL NLKEYNLV
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