ID G1QRY7_NOMLE Unreviewed; 3801 AA.
AC G1QRY7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Lysosomal trafficking regulator {ECO:0000313|Ensembl:ENSNLEP00000003705.2};
GN Name=LYST {ECO:0000313|Ensembl:ENSNLEP00000003705.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003705.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003705.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003705.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01036947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01036956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000003705; -.
DR Ensembl; ENSNLET00000003888.3; ENSNLEP00000003705.2; ENSNLEG00000002982.3.
DR eggNOG; KOG1786; Eukaryota.
DR GeneTree; ENSGT00940000156359; -.
DR HOGENOM; CLU_000213_1_0_1; -.
DR InParanoid; G1QRY7; -.
DR OMA; MGAPPEF; -.
DR TreeFam; TF313658; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3009..3115
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3120..3422
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3612..3646
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1181..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3801 AA; 429253 MW; 65C75D7FDF103CAC CRC64;
MSTDSNSLAR EFLTDVNRLC NAVVQRVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE EKATDFNLPL SADIILTKEK NSSSQRSTQE
KLHLEGSVLS SQVSAKVNVF RKSRRQRKIT HRYSIRDARK TQLSTSDSEA NSDEKGIAMN
KHRRPHLLQH FVTSFPKQDH PKAKLDHLAT KEEQTPPDAM ALENSREIIP RQESNTDILS
EPAALSVISN MNNSPFDLCH VLLSLLEKVC KFDITLNHSS PLAASVVPTL TEFLAGFGDC
CSLSDNLESR VVSAGWTEEP VALIQRMLFR TVLHLLSVDV STAEMMPENL RKNLTELLRA
ALKIRIWLEK QPDPFAPRQK KTLQEVQEDF VFSKYRHRAL LLPELLEGVL QILICCLQSA
ASNPFYFSQA VDLVQEFIQH HGFNLFETAV LQMEWLVLRN GVPPEASEHL KALINSVMKI
MSTVKKVKSE QLHHSMCTRK RHRRCEYSHF MHHHRDLSGL LVSAFKNQVS KNPFEETADG
DVYYPERCCC IAVCAHQCLR LLQQASLSST CVQILLGIHN IGICCCMDPK SVIIPLLHAF
KLPALKNFQQ HILNILNKLI LDQLGGAEIS PKIKKAACNI CTVDSDQLAQ LEETLQGNLC
DAEPSSSLSS PSYRFQGILP SSGSEDLLWK WDALKAYQNF VFEEDRLHSI QIANHICNLI
QKGNIVVQWK LYNYIFNPVL QRGVELAHHC QHLSITSAQS HICSHHNQCL PQDVLQVYVK
TLPILLKSRV IRDLFLSCNG VSQIIELNYL NGIRSHSLKA FETLIISLGE QQKDASVPGI
EGIDTEQKEL SSVHEGTSFH HQQAYSDSPQ SLSKFYAGLK EAYPKRWKTV NQDVHINTIN
LFLCVAFLCI SKEAESDRES ANDSEDTSGY DSTASEPLSH MLPCLSLESL VLPSPEYMHQ
AADIWSMCRW IYMLSSVFQK QFYRLGGFRV CHKLIFMIIQ KLFRSRKEEQ GKKEEDTNVN
ENQDINRISQ PEITVKEDLL SLTTKSDPIP SELGSLKKSA DSLGKLELQH ISSINVEQVS
ATEAAPEEAK IFTSPESETS LQSIRLLEAL LAICLHGART SQQKMELELP NQNLSVENIL
FEMRDHLSQS KVIETQLAKP LFDALLRVAL GNYSADFEHN DAMTEKSHQS AEELSSQPGD
FSEEAEDSQC CSFKLLVEEE GYEADSESNP EDGETQDDGV DLKSETEGFS ASSSPNDLLE
NLTQGEIIYP EICMLELNLL SASKAKLDVL AHVFESFLKI IRQKEKNVFL LMQQGTVKNL
LGGFLSILTQ ADSDFQACQR VLVDLLVSLM SSRTCSEELT LLLRIFLEKS PCTKILLLGI
LKIIESDTTM SPSQYLTFPL LHTPNLSNGV SSQKYPGILN SKAMGLLRRA RVSRSKKEAD
RESFPHRLLS SWHIAPVHLP LLGQNCWPHL SEGFSVSLWF NVECIHEAES TTEKGKKIKK
RNKSLILPDS SFDGTESDRP EGAEYINPGE RLIEEGCIHI ISLGSKALMI QVWADPHNAT
FIFRVCMDSN DDVKAVLLAQ VESQENIFIP SKWQHLVLTY LQQPQGKRRI HGKISIWVSG
QRKPDVTLDF MLPRKTSLSS DSNKTFCMIG HCLSSQEEFL QLAGKWDLGN LLLFNGAKVG
SQEAFYLYAC GPNHTSVMPC KYGKPVNDYS KYINKEILRC EQIRELFMTK KDVDIGLLIE
SLSVVYTTYC PAQYTIYEPV IRLKGQMKTQ LSQRPFSSKE VQSILLEPHH LKNLQPTEYK
TIQGILHEIG GTGIFVFLFA RVVELSSCEE TQALALQVIL SLIKYNQQRV HELENCNGLS
MIHQVLIKQK CIVGFYILKT LLEGCCGEDI IYMNENGEFK LDVDSNAIIQ DVKLLEELLL
DWKIWNKAEQ GVWETLLAAL EVLIRADHHQ QMFNIKQLLK AQVVHHFLLT CQVLQEHKEG
QLTPMPREVC RSFVKIIAEV LGSPPDLELL TIIFNFLLAV HPPTNTYVCH NPTNFYFSLH
IDGKIFQEKV RSIMHLRHSS SGGRSLVSPG FMVISPSGFT ASPYEGENSS NIIPQQMAAH
MLRSRSLPAF PTSSLLMQSQ KLTGSLGCSI DRLQNIADTY VATQSKKQNS LGSSDTLKKG
KEDAFISSCE SAKTVCEMEA VLSAQVSVSD VQKGVLGFPV VKADHKELGA EPRLEDDSPG
DESCPCRPDY LKGLASFQRS HSTIASLGLA FPSQNGSAAV GRWPSLVDRN TDDWETFAYS
LGYEPNYSRT ASAHSVTEDC LVPICCGLYE LLSGVLLILP DVMLEDVMDK LIQADTLLVL
VNHPSPAIQQ GVIKLLDAYF ARASKEQKDK FLKNRGFSLL ANQLYLHRGT QELLECFIEM
FFGRHIGLDE EFDLEDVRNM GLFQKWSVIP ILGLIETSLY DNILLHNALL LLLQILNSCS
KVADMLLDNG LLYVLCNTVA ALNGLEKNIP VSEYKLLACD IQQLFIAVTI HACSSSGSQY
FRVIEDLIVM LGYLQNSKNK RTQNMAVALQ LRVLQAAMEF IRTTANHDSE NLTDSLQSPS
APHHAIVQKR KSIAGPRKFP LAQTESLLMK MRSVANDELH VMMQRRMSQE NPSQATETEL
AQRLQRLTVL AVNRIIYQEF NSDIIDILRT PENVTQSKTS VFQTEISEEN THHEQSSVFN
PFQKEIFTYL VEGFKVSIGS SKASGSKQQW TKILWSCKET FXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXEILRDC LSPSLQHGAK LVLYLSELIH NHQDELTEEE LDTAELLMNA
LKLCGHKCIP PSASTKADLI KMIKEEQKKY ETEEGVNKAA WQKTVNNNQQ SLFQRLDSKS
KDISKIAADI TQAVSLSQGI ERKKVIQHIR GMYKVDLSAS RHWQELIQQL THDRAVWYDP
IYYPTSWQLD PTEGPNRERR RLQRCYLTIP NKYLLRDRQK SEDVVKPPLS YLFEDKTHSS
FSSTVKDKAA SESIRVNRRC ISVAPSRETA GELLLGKCGM YFVEDNASDT IESSSLQGEL
EPASFSWTYE EIKEVHKRWW QLRDNAVEIF LTNGRTLLLA FDNTKVRDDV YHNILTNDLP
NLLEYGNITA LTNLWYTGQI TNFEYLTHLN KHAGRSFNDL MQYPVFPFIL ADYVSETLDL
NDPLIYRNLS KPIAVQYKEK EDRYVDTYKY LEEEYRKGAR EDDPMPPVQP YHYGSHYSNS
GTVLHFLVRM PPFTKMFLAY QDQSFDIPDR TFHSTNTTWR LSSFESMTDV KELIPEFFYL
PEFLVNREGF DFGVRQNGER VNHVNLPPWA RNDPRLFILI HRQALESDYV SQNICQWIDL
VFGYKQKGKA SVQAINVFHP ATYFGMDVSA VEDPVQRRAL ETMIKTYGQT PRQLFHTAHV
SRPGAKLNIE GELPAAVGLL VQFAFRETRE QVKEITYPSP LSWIKGLKWG EYVGSPSAPV
PMVCFSQPHG ERFGSLQALP TRAICGLSRN FCLLMTYSKE QGVRSMNSTD IQWSAILSWG
YADNILRLKS KQSEPPVNFI QSSQQYQVTS CAWVPDSCQL FTGSKCGVIT AYTNRLTSST
PSEIEMETQI HLYGHTEEIT SLFVCKPYSI LISVSRDGTC IIWDLNRLCY VQSLAGHKSP
VTAVSASETS GDIATVCDSA GGGSDLRLWT VNGDLVGHVH CREIICSVAF SNQPEGISIN
VIAGGLENGI VRLWSTWDLK PVREITFPKS NKPIISLTFS CDGHHLYTAN SDGTVIAWCR
KDQQRLKQPM FYSFLSSYAA G
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