ID G1QTJ3_NOMLE Unreviewed; 252 AA.
AC G1QTJ3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Oncostatin M {ECO:0000313|Ensembl:ENSNLEP00000004261.1};
GN Name=OSM {ECO:0000313|Ensembl:ENSNLEP00000004261.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004261.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004261.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004261.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the LIF/OSM family.
CC {ECO:0000256|ARBA:ARBA00005971}.
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DR EMBL; ADFV01177629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003258113.1; XM_003258065.3.
DR AlphaFoldDB; G1QTJ3; -.
DR STRING; 61853.ENSNLEP00000004261; -.
DR Ensembl; ENSNLET00000004484.3; ENSNLEP00000004261.1; ENSNLEG00000003527.3.
DR GeneID; 100603259; -.
DR KEGG; nle:100603259; -.
DR CTD; 5008; -.
DR eggNOG; ENOG502RVJA; Eukaryota.
DR GeneTree; ENSGT00390000004850; -.
DR HOGENOM; CLU_102028_0_0_1; -.
DR InParanoid; G1QTJ3; -.
DR OMA; FMHSVGQ; -.
DR OrthoDB; 4641001at2759; -.
DR TreeFam; TF338204; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
DR GO; GO:0005147; F:oncostatin-M receptor binding; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0046888; P:negative regulation of hormone secretion; IEA:Ensembl.
DR GO; GO:0038165; P:oncostatin-M-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR InterPro; IPR039578; OSM.
DR PANTHER; PTHR14261; ONCOSTATIN M; 1.
DR PANTHER; PTHR14261:SF0; ONCOSTATIN-M; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00590; LIF_OSM; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..252
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003418952"
FT REGION 162..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..246
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 28459 MW; D045BB2DBC676D8E CRC64;
MGVPLTQRTL LSLVLALLFA SMASMAAIGS CSREYHVLLG QLQKQTDLMQ DTSRLLDPYI
RIQGLDVPKL REHCRERPGA FPSEETLRGL GRRGFLQTLN ATLGCVLHRL ANLEQHLPKA
QDLERSGLNI EDLEKLQMAR PNVLGLRNNI YCMAQLLDNS DTAEPTKAGR GASQPPTPTP
ASDAFQRKLE GCRFLRGYHR FMHSVGWVFS KWGESPNRSR RHSPHQALQK GMHRIRPSRK
GKRLMPRGQL PR
//
