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Database: UniProt
Entry: G1QTU4_NOMLE
LinkDB: G1QTU4_NOMLE
Original site: G1QTU4_NOMLE 
ID   G1QTU4_NOMLE            Unreviewed;      4386 AA.
AC   G1QTU4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 48.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSNLEP00000004362};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSNLEP00000004362};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004362};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000004362}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000004362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; ADFV01037095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000004362; -.
DR   Ensembl; ENSNLET00000004591; ENSNLEP00000004362; ENSNLEG00000003602.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1QTU4; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001073; Chromosome 5.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3715   3734       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3935   3955       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4009   4028       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4186   4208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4263   4286       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      128    328       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      534    731       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3465   3500       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2527   2547       {ECO:0000256|SAM:Coils}.
FT   COILED     2792   2812       {ECO:0000256|SAM:Coils}.
FT   COILED     3847   3880       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4386 AA;  498994 MW;  B7BC2C56506A0708 CRC64;
     MVYFRGLDAL SKKAKAATVD LPIESVSLSL QDLIEVRVYQ HSLLFCYRLH VYSSAAHFAD
     VAGREAGESW KSILNSLYEL LAALIRGNRK NCAQFSGSLD WLISRLERLE ASSGILEVLH
     CVLVESPEAL NIIKEGHIKS IISLLDKHGR NHKVLDVLCS LCVCHGVAVR SNQHLICDNL
     LPGRDLLLQT RLVNHVSSMR PIFFLGVSEV LNSLRVGWAS TEGYSPYPGG GEEWGGNGVG
     DDLFSYGFDG LISGCIARTV SSPNQHLLRT DDVISCCLDL SAPSISFRIN GQPVQGMFEN
     FNIDGLFFPV VSFSAGIKVR FLLGGRHGEF KFLPPPGYAP CYEAVLPKEK LKVEHSREYK
     QERTYTRDLL GPTVSLTQAA FTPIPVDTSQ IVLPPHLERI REKLAENIHE LWVMNKIELG
     WQYGPVRDDN KRQHPCLVEF SKLPEQERNY NLQMSLETLK DFYEKANSIQ ISLSLIHSYQ
     LTSGYKPAPM DLSFIKLTPS QEAMVDKLAE NAHNVWARDR IRQGWTYGIQ QDVKNRRNPR
     LVPYTLLDDR TKKSNKDSLR EAVRTLLGYG YNLEAPDQDH AARAEVCSGT GERFRIFRAE
     KTYAVKAGRW YFEFETVTAG DMRVGWSRPG CQPDQELGSD ERAFAFDGFK AQRWHQGNEH
     YGRSWQAGDV VGCMVDMNEH TMMFTLNGEI LLDDSGSELA FKDFDVGDGF IPVCSLGVAQ
     VGRMNFGKDV STLKYFTICG LQEGYEPFAV NTNRDITMWL SKRLPQFLQV PSNHEHIEVT
     RIDGTIDSSP CLKVTQKSFG SQNSNTDIMF YRLSMPIECA EVFSKTVAGG LSGAGLFGPK
     NDLEDYDADS DFEVLMKTAH GHLVPDRVDK DKEATKPEFN NHKDYAQEKP SRLKQRFLLR
     RTKPDYSTSH SARLTEDVLA DDRDDYDFLM QTSTYYYSVR IFPGQEPANV WVGWITSDFH
     QYDTGFDLDR VRTVTVTLGD EKGKVHERLV FLNFFARMTC EKNIGEPSYS FSLYFELSTY
     YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL FKSEHKNPVP QCPPRLHVQF
     LSHVLWSRMP NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL HIPEENRSVD ILELTEQEEL
     LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE NKYMPGLLRA GYYDLLIDIH
     LSSYATARLM MNNEYIVPMT EETKSITLFP DENKKHGLPG IGLSTSLRPR MQFSSPSFVS
     ISNECYQYSP EFPLDILKAK TIQMLTEAVK EGSLHARDPV GGTTEFLFVP LIKLFYTLLI
     MGIFHNEDLK HILQLIEPSV FKEAATPEEE SDTLEKEFSV DDAKLQGAGE EEAKGGKRPK
     EGLLQMKLPE PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA
     LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH EDLMTHCGIE
     LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQAEKPVES DSKKSSTLQQ LISETMVRWA
     QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTING VSVEDTINLL ASLGQIRSLL
     SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP
     KMVANCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN
     NELALALREP DLEKVVRYLA GCGLQSCQML VSKGYPDIGW NPSVEENANV VVRLLIRRPE
     CFGPALRGEG GNGLLAAMEE AIKIAEDPSR DGPSPNSGST KTLDTEEEED DTIHMGNAIM
     TFYAALIDLL GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIA FQMPTIAKDG
     NVVEPDMSAG FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA ASLDTAALSA
     TDMALALNRY LCTAVLPLLT RCAPLFAGTE HHASLIDSLL HTVYRLSKGC SLTKAQRDSI
     EVCLLSICGQ LRPSMMQHLL RRLVFDVPLL NEHAKMPLKL LTNHYERCWK YYCLPGGWGN
     FGAASEEELH LSRKLFWGIF DALSQKKYEQ ELFKLALPCL SAVAGALPPD YMESNYVSMM
     EKQSSMDSEG NFNPQPVDTS NITIPEKLEY FINKYAEHSH DKWSMDKLAN GWIYGEIYSD
     SSKVQPLMKP YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA LYNRTRRISQ
     TSQVSVDAAH GYSPRAIDMS NVTLCRDLHA MAEMMAENYH NIWAKKKKME LESKGGGNHP
     LLVPYDTLTA KEKAKDREKA QDILKFLQIN GYAVSRGFKD LELDTPSIEK RFAYSFLQQL
     IRYVDEAHQY ILEFDGGSRG KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSAASRP
     LCSGGHASNK EKEMNIEKFS GQFIRHFVSS LGNDATSIVN CLHILGQTLD ARTVMKTGLE
     SVKSALRAFL DNAAEDLEKT MENLKQGQFT HTRNQPKGVT QIINYTTVAL LPMLSSLFEH
     IGQHQFGEDL ILEDVQVSCY RILTSLYALG TSKSIYVERQ RSALGECLAA FAGAFPVAFL
     ETHLDKHNIY SIYNTKSSRE RAALSLPTNV EDVCPNIPSL EKLMEEIVEL AESGIRYTQM
     PHVMEVILPM LCSYMSRWWE HGPENNPERA EMCCTALNSE HMNTLLGNIL KIIYNNLGID
     EGAWMKRLAV FSQPIINKVK PQLLKTHFLP LMEKLKKKAA MVVSEEDHLK AEARGDMSEA
     ELLILDEFTT LARDLYKYLY PFLIILIYQI NTYLCKNLQV LLVLTEISFA TSQNFKREEQ
     NFVVQNEINN MSFLITDTKS KMSKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG
     LNICAPGDQE LIALAKNRFS LKDTEDEVRD IIRSNIHLQG KLEDPAIRWQ MALYKDLPNR
     TDDTSDPEKT VERVLDIANV LFHLEQVRLC VNSIIFALVE HPQRSKKAVW HKLLSKQRKR
     AVVACFRMAP LYNLPRHRAV NLFLQGYEKS WIETEEHYFE DKLIEDLAKP GAEPPEEDEG
     TKRVDPLHQL ILLFSRTTPS CHDEEDDDGE EEVKSFEEKE MEKQKLLYQQ ARLHDRGAAE
     MVLQTISASK GETGPMVAAT LKLGIAILNG GNSTVQQKML DYLKEKKDVG FFQSLAGLMQ
     SCSVLDLNAF ERQNKAEGLG MVTEEGSGEK VLQDDEFTCD LFRFLQLLCE GHNSDFQNYL
     RTQTGNNTTV NIIISTVDYL LRVQESISDF YWYYSGKDVI DEQGQRNFSK AIQVAKQVFN
     TLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMQMKL SQDSSQIELL KELMDLQKDM
     VVMLLSMLEG NVVNGTIGKQ MVDMLVESSN NVEMILKFFD MFLKLKDLTS SDTFKEYDPD
     GKGVISKRDF HKAMESHKHY TQSETEFLLS CAETDENETL DYEEFVKRFH EPAKDIGFNV
     AVLLTNLSEH MPNDTRLQTF LELAESVLNY FQPFLGRIEI MGSAKRIERS SRTQWEKPQV
     KESKRQFIFD VVNEGGEKEK MELFVNFCED TIFEMQLAAQ ISESDLNERS ANKEESEKER
     PEEQGPRMAF FSILTVKSAL FALRYNILTL MRMLSLKSLK KQMKKVKKMT VKDMVTAFFS
     SYWSIFMTLL HFVASVFRGF FRIVCSLLLG GSLVEGAKKI KVAELLANMP DPTQDEVRGD
     GEEGERKPLE AALPSEDLTD LKELTEESDL LSDIFGLDLK REGGQYKLIP HNPNAGLSDL
     MSNPVPMPEV QEKFQEQKAK EEEKEEKEET KSEPEKAEGE DGEKEEKAKE DKGKQKLRQL
     HTHRYGEPEV PESAFWKKII AYQQKLLNYF ARNFYNMRML ALFVAFAINF ILLFYKVSTS
     SVVEGKELPT RSSSENAKVT SLDSSSHRII AVHYVLEESS GYMEPTLRIL AILHTVISFF
     CIIGYYCLKV PLVIFKREKE VARKLEFDGL YITEQPSEDD IKVNNYVRLS VMDKYGEFYG
     RDRISELLGM DKAALDFSDA REKKKPKKDS SLSAVLNSID VKYQMWKLGV VFTDNVILPL
     PRLVYDYVCL GHYNNFFFAA HFLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY
     TVVAFNFFRK FYNKSEDGDT PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI
     YRIIFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV
     PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW KMYQERCWEF FPAGDCFRKQ
     YEDQLN
//
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