ID G1QTU7_NOMLE Unreviewed; 573 AA.
AC G1QTU7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Nuclear receptor subfamily 1 group D member 2 {ECO:0000313|Ensembl:ENSNLEP00000004365.3};
GN Name=NR1D2 {ECO:0000313|Ensembl:ENSNLEP00000004365.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004365.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004365.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004365.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR EMBL; ADFV01171690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01171691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01171692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01171693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QTU7; -.
DR Ensembl; ENSNLET00000004594.3; ENSNLEP00000004365.3; ENSNLEG00000003588.3.
DR eggNOG; KOG4846; Eukaryota.
DR GeneTree; ENSGT00940000155168; -.
DR HOGENOM; CLU_007368_2_4_1; -.
DR TreeFam; TF328382; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07166; NR_DBD_REV_ERB; 1.
DR CDD; cd06940; NR_LBD_REV_ERB; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF112; NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 94..170
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 363..573
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 64085 MW; 89591640CC085C47 CRC64;
GVIAYISSSS SASSPASCHS EGSENSFQSS SSSVPSSPNS SNSDTNGNPK NGDLSNIEGI
LKNDRIDCSM KTSKSSAPGM TKSHSGVTKF SGMVLLCKVC GDVASGFHYG VHACEGCKGF
FRRSIQQNIQ YKKCLKNENC SIMRMNRNRC QQCRFKKCLS VGMSRDAVRF GRIPKREKQR
MLIEMQSAMK TMMNSQFSGH LQNDTLVEHH EQTALPAQEQ LRPKPQLEQE NIKSSSPPSS
DFAKEEVIGM VTRAHKDTFM YNQEQRENSA ESMQPQRGER IPKNMEQYNL NHDHCGNGLS
SHFPCSESQQ HLNGQFKGRN IMHYPNGHAI CIANGHCMNF SNAYTQRVCD RVPIDGFSQN
ENKNSYLCNT GGRMHLVCPM SKSPYVDPHK SGHEIWEEFS MSFTPAVKEV VEFAKRIPGF
RDLSQHDQVN LLKAGTFEVL MVRFASLFDA KERTVTFLSG KKYSVDDLHS MGAGDLLNSM
FEFSEKLNAL QLSDEEMSLF TAVVLVSADR SGIENVNSVE ALQETLIRAL RTLIMKNHPN
EASIFTKLLL KLPDLRSLNN MHSEELLAFK VHP
//
