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Database: UniProt
Entry: G1QTW5_NOMLE
LinkDB: G1QTW5_NOMLE
Original site: G1QTW5_NOMLE 
ID   G1QTW5_NOMLE            Unreviewed;       310 AA.
AC   G1QTW5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   05-DEC-2018, entry version 36.
DE   SubName: Full=Glyoxylate and hydroxypyruvate reductase {ECO:0000313|Ensembl:ENSNLEP00000004385};
GN   Name=GRHPR {ECO:0000313|Ensembl:ENSNLEP00000004385};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004385};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000004385}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000004385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   EMBL; ADFV01016519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01016520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000004385; -.
DR   Ensembl; ENSNLET00000004616; ENSNLEP00000004385; ENSNLEG00000003637.
DR   eggNOG; KOG0069; Eukaryota.
DR   eggNOG; COG1052; LUCA.
DR   GeneTree; ENSGT00940000158578; -.
DR   InParanoid; G1QTW5; -.
DR   OrthoDB; EOG091G0VB7; -.
DR   TreeFam; TF324791; -.
DR   Proteomes; UP000001073; Chromosome 8.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN       28    307       2-Hacid_dh. {ECO:0000259|Pfam:PF00389}.
FT   DOMAIN       98    277       2-Hacid_dh_C. {ECO:0000259|Pfam:PF02826}.
SQ   SEQUENCE   310 AA;  33808 MW;  DDEEF5B05B854095 CRC64;
     MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGANLKVI
     STMSVGFDHL ALDEIKKRGI RVGYTPDVLT DTTAELAVSL LLTTCRRLPE AIEEVKNGGW
     TSWKPLWLCG YGLTQSTVGI IGLGRIGQAI ARRLKPFGVQ RFLYTGRQPR PEEAAEFQAE
     FVSTPELAAQ SDFIIVACSL TPATEGLCNK DFFQKMKETA VFINISRGDV VNQDDLYQAL
     ASGKIAAAGL DVTSPEPLPT NHPLLTLKNC VILPHIGSAT YRTRNTMSLL AANNLLAGLR
     GEPMPSELKL
//
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