ID G1QU37_NOMLE Unreviewed; 259 AA.
AC G1QU37;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=CD27 molecule {ECO:0000313|Ensembl:ENSNLEP00000004457.1};
GN Name=CD27 {ECO:0000313|Ensembl:ENSNLEP00000004457.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004457.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004457.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004457.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; ADFV01078454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01078455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QU37; -.
DR STRING; 61853.ENSNLEP00000004457; -.
DR Ensembl; ENSNLET00000004692.2; ENSNLEP00000004457.1; ENSNLEG00000003696.2.
DR eggNOG; ENOG502SBE3; Eukaryota.
DR GeneTree; ENSGT00510000049297; -.
DR HOGENOM; CLU_067121_0_0_1; -.
DR InParanoid; G1QU37; -.
DR OMA; LSTHWSP; -.
DR TreeFam; TF336960; -.
DR Proteomes; UP000001073; Chromosome 23.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IEA:Ensembl.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:InterPro.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:InterPro.
DR CDD; cd13408; TNFRSF7; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022328; TNFR_7.
DR InterPro; IPR034000; TNFRSF7_N.
DR PANTHER; PTHR47496; CD27; 1.
DR PANTHER; PTHR47496:SF1; CD27 ANTIGEN; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01960; TNFACTORR7.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..259
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003420121"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 64..104
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 64..104
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 218..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 259 AA; 29053 MW; 19CDA3A00B05AEF2 CRC64;
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA
QCEPCIPGVS FSPDHHSRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC
DPLPNPSLTT QPSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP
QRSLCSSDLI RILVIFSGMF LVFTLAGALF LHQQRKYRSN KGESPVEPAE CRYSCPREEE
GSTIPIQEDY RKPEPAFSP
//
