ID G1QU55_NOMLE Unreviewed; 459 AA.
AC G1QU55;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=calcium/calmodulin-dependent protein kinase {ECO:0000256|ARBA:ARBA00012434};
DE EC=2.7.11.17 {ECO:0000256|ARBA:ARBA00012434};
GN Name=CAMK2B {ECO:0000313|Ensembl:ENSNLEP00000004475.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004475.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004475.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004475.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000902};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.17; Evidence={ECO:0000256|ARBA:ARBA00000517};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. CaMK subfamily. {ECO:0000256|ARBA:ARBA00005354}.
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DR EMBL; ADFV01046846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01046855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QU55; -.
DR Ensembl; ENSNLET00000004710.2; ENSNLEP00000004475.3; ENSNLEG00000003715.2.
DR GeneTree; ENSGT00940000158973; -.
DR HOGENOM; CLU_000288_71_3_1; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:UniProtKB-EC.
DR CDD; cd14086; STKc_CaMKII; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013543; Ca/CaM-dep_prot_kinase-assoc.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24347:SF403; CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA; 1.
DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF08332; CaMKII_AD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1..213
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 266..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 51176 MW; 3DEA61C1D11A258D CRC64;
GAFSVVRRCV KLCTGHEYAA KIINTKKLSA RKHSNIVRLH DSISEEGFHY LVFDLHCIQQ
ILEAVLHCHQ MGVVHRDLKP ENLLLASKCK GAAVKLADFG LAIEVQGDQQ AWFGFAGTPG
YLSPEVLRKE AYGKPVDIWA CGVILYILLV GYPPFWDEDQ HKLYQQIKAG AYDFPSPEWD
TVTPEAKNLI NQMLTINPAK RITAHEALKH PWVCQRSTVA SMMHRQETVE CLKKFNARRK
LKGAILTTML ATRNFSAAKS LLNKKADGVK PQTNSTKNSA AATSPKGTLP PAALEPQTTV
IHNPVDGIKE SSDSANTTIE DEDAKARKQE IIKTTEQLIE AVNNGDFEAY AKICDPGLTS
FEPEALGNLV EGMDFHRFYF ENLLAKNSKP IHTTILNPHV HVIGEDAACI AYIRLTQYID
GQGRPRTSQS EETRVWHRRD GKWQNVHFHC SGAPVAPLQ
//
