ID G1QVH9_NOMLE Unreviewed; 507 AA.
AC G1QVH9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 08-NOV-2023, entry version 65.
DE SubName: Full=Acid sensing ion channel subunit 3 {ECO:0000313|Ensembl:ENSNLEP00000004950.2};
GN Name=ASIC3 {ECO:0000313|Ensembl:ENSNLEP00000004950.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004950.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004950.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004950.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; ADFV01062550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01062551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QVH9; -.
DR STRING; 61853.ENSNLEP00000004950; -.
DR Ensembl; ENSNLET00000005206.2; ENSNLEP00000004950.2; ENSNLEG00000004089.3.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000162081; -.
DR HOGENOM; CLU_020415_1_2_1; -.
DR InParanoid; G1QVH9; -.
DR OMA; GQFHHVT; -.
DR TreeFam; TF330663; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042931; F:enterobactin transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0050968; P:detection of chemical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0010447; P:response to acidic pH; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690:SF228; ACID-SENSING ION CHANNEL 3; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}.
FT REGION 285..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 507 AA; 56069 MW; A076574C890F61B8 CRC64;
MKPTSGPEEA RQPASAIRVF ASNCSMHGLG HVFGPGSLSL RRGMWAAAVV LSVATFLYQA
AERVRYYREF HHQTALDERE SHRLVFPAVT LCNINPLRRS RLTPNDLHWA GSVLLGLDPS
EHTAFLRALG RPPAPPGFMP SPTFDMAQLY ARAGHSLDDM LLDCRFRGQP CGPENFTTIF
TRMGKCYTFN SGADGAELLT TTRGGMGNGL DIMLDVQQEE YLPVWRDDEE TPFEVGIRVQ
IHSQEEPPII DQLGLGVSPG YQTFVSCQQQ QLSFLPPPWG DCSSASLNPN YEPEPSDPLG
SLSPSPSPIP PYTLMGCRLA CETRYVARKC GCRMMYMPGD APVCSPQQYK NCAHPAIDAM
LRKDPCACPN PCASTRYAKE LSMVRIPSRA AARFLARKLN RSEAYISLLT ILEILDYLCE
VFRDKVLRYF WNRRHSQRHS STNLLQEGLG SHRTQVPHLN LGPSTLLFSE DLPPLPVPSP
RLSPPPTAPA TLSHSSRPAV CVLGAPP
//