ID   G1QVT3_NOMLE            Unreviewed;       521 AA.
AC   G1QVT3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Glutamate decarboxylase like 1 {ECO:0000313|Ensembl:ENSNLEP00000005054.1};
GN   Name=GADL1 {ECO:0000313|Ensembl:ENSNLEP00000005054.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005054.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000005054.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000005054.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|ARBA:ARBA00009533, ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; ADFV01171925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01171926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01171927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01171928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01171929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003256851.1; XM_003256803.1.
DR   AlphaFoldDB; G1QVT3; -.
DR   STRING; 61853.ENSNLEP00000005054; -.
DR   Ensembl; ENSNLET00000005314.3; ENSNLEP00000005054.1; ENSNLEG00000004173.3.
DR   GeneID; 100607408; -.
DR   KEGG; nle:100607408; -.
DR   CTD; 339896; -.
DR   eggNOG; KOG0629; Eukaryota.
DR   GeneTree; ENSGT00940000158391; -.
DR   HOGENOM; CLU_011856_0_0_1; -.
DR   InParanoid; G1QVT3; -.
DR   OMA; NWQPLMV; -.
DR   OrthoDB; 888358at2759; -.
DR   TreeFam; TF314688; -.
DR   Proteomes; UP000001073; Chromosome 4.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.170; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   PANTHER; PTHR45677:SF1; ACIDIC AMINO ACID DECARBOXYLASE GADL1; 1.
DR   PANTHER; PTHR45677; GLUTAMATE DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         333
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   521 AA;  59288 MW;  0FFF8261EE077341 CRC64;
     MSSNSDRQCP VDGDTDQQEM IPSKKNAVLV DGVVLNGPTT DAKAGEKFVE EACRLIMEEV
     VLKATDVNEK VCEWRPPEQL KQLLDLEMRD SGEPLHKLLE LCRDVIRYSV KTNHPRFFNQ
     LYAGLDYYSL VARFMTEALN PSVYTYEVSP VFLLVEEAVL KKMIEFIGWK EGDGIFNPGG
     SVSNMYAMNL ARYKYCPDIK EKGLSGSPRL ILFTSAECHY SMKKAASFLG IGTENVCFVE
     TDGRGKMIPE ELEKQVWQAR KEGAAPFLVC ATSGTTVLGA FDPLDEIADI CERHSLWLHV
     DASWGGSALM SRKHRKLLRG IHRADSVAWN PHKMLMAGIQ CCALLVKDKS DLLKKCYSAK
     ASYLFQQDKF YDVSYDTGDK SIQCSRRPDA FKFWMTWKAL GTLGLEERVN RALALSRYLV
     DEIKKREGFK LLMEPEYANI CFWYIPPSLR EMEEGPEFWA KLNLVAPAIK ERMMKKGSLM
     LGYQPHRGKV NFFRQVVISP QVSREDMDFL LDEIDLLGKD M
//