ID G1QW43_NOMLE Unreviewed; 2534 AA.
AC G1QW43;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Talin 1 {ECO:0000313|Ensembl:ENSNLEP00000005164.2};
GN Name=TLN1 {ECO:0000313|Ensembl:ENSNLEP00000005164.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005164.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005164.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005164.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01016696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01016697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01016698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01016699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000005427.2; ENSNLEP00000005164.2; ENSNLEG00000004224.3.
DR eggNOG; KOG4261; Eukaryota.
DR GeneTree; ENSGT00940000157006; -.
DR HOGENOM; CLU_000364_1_1_1; -.
DR TreeFam; TF314677; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17171; FERM_F0_TLN1; 1.
DR CDD; cd17173; FERM_F1_TLN1; 1.
DR CDD; cd12150; talin-RS; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 7.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037438; Talin1/2-RS.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981; TALIN; 1.
DR PANTHER; PTHR19981:SF7; TALIN-1; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 2.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 5.
DR SUPFAM; SSF109885; I/LWEQ domain; 4.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 95..416
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2286..2526
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 398..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1017..1070
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2456..2521
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2534 AA; 268781 MW; 690ED690A55AF9F2 CRC64;
PGWRKEAATM VALSLKISIG NVVKTMQFEP STMVYDACRI IRERIPEAPA GPPSDFGLFL
SDDDPKKGIW LEAGKALDYY MLRNGDTMEY RKKQRPLKIR MLDGTVKTIM VDDSKTVTDM
LMTICARIGI TNHDEYSLVR ELMEEKKEEV TGTLRKDKTL LRDEKKMEKL KQKLHTDDEL
NWLDHGRTLR EQGVEEHETL LLRRKFFYSD QNVDSRDPVQ LNLLYVQARD DILNGSHPVS
FDKACEFAGF QCQIQFGPHN EQKHKGCLKD FLPKEYVKQK GERKIFQAHK NCGQMSEIEA
KVRYVKLARS LKTYGVSFFL VKEKMKGKNK LVPRLLGITK ECVMRVDEKT KEVIQEWNLT
NIKRWAASPK SFTLVSLGTP TRKCFGSLRK GAAAEKKSKD HFGLEGDEES TMLEDSVSPK
KSTVLQQQYN RVGKVEHGSV ALPAIMRSGA SGPENFQVGS MPPAQQQITS GQMHRGHMPP
LTSAQQALTG TINSSMQAVQ AAQATLDDFD TLPPLGQDAA SKAWRKNKMD ESKHEIHSQV
DAITAGTASV VNLTAGDPAE TDYTAVGCAV TTISSNLTEM SRGVKLLAAL LEDEGGSGRP
LLQAAKGLAG AVSELLRSAQ PASAEPRQNL LQAAGNVGQA SGELLQQIGE SDTDPHFQDV
LMQLAKAVAS AAAALVLKAK SVAQRTEDSG LQTQVIAAAT QCALSTSQLV ACTKVVAPTI
SSPVCQEQLV EAGRLVAKAV EGCVSASQAA TEDGQLLRGV GAAATAVTQA LNELLQHVKA
HAIGAGPAGR YDQATDTILT VTENIFSSMG DAGEMVRQAR ILAQATSDLV NAIKADAEGE
SDLENSRKLL SAAKILADAT AKMVEAAKGA AAHPDSEEQQ QRLREAAEGL RMATNAAAQN
AIKKKLVQRL EHAAKQAAAS ATQTIAAAQH AASTPKASAG PQPLLVQSCK AVAEQIPLLV
QGVRGSQAQP DSPSAQLALI AASQSFLQPG GKMVAAAKAS VPTIQDQASA MQLSQCAKNL
GTALAELRTA AQKAQEACGP LEMESALSVV QNLEKDLQEV KAAARDGKLK PLPGETMEKC
TQDLGNSTKA VSSAIAQLLG EVAQGNENYA GIAARDVAGG LRSLAQAARG VAALTSDPAV
QAIVLDTASD VLDKASSLIE EAKKAAGHPG DPESQQRLAQ VAKAVTQALN RCVSCLPGQR
DVDNALRAVG DASKRLLSDS LPPSTGTFQE AQSRLNEAAA GLNQAATELV QASRGTPQDL
ARASGRFGQD FSTFLEAGVE MAGQAPSQED RAQVVSNLKG ISMSSSKLLL AAKALSTDPA
APNLKSQLAA AARAVTDSIN QLITMCTQQA PGQKECDNAL RELETVRELL ENPVQPINDM
SYFGCLDSVM ENSKVLGEAM TGISQNAKNG NLPEFGEAIS TASKALCGFT EAAAQAAYLV
GVSDPNSQAG QQGLVEPTQF ARANQAIQMA CQSLGEPGCT QAQVLSAATI VAKHTSALCN
SCRLASARTT NPTAKRQFVQ SAKEVANSTA NLVKTIKALD GAFTEENRAQ CRAATAPLLE
AVDNLSAFAS NPEFSSIPAQ ISPEGRAAME PIVISAKTML ESAGGLIQTA RALAVNPRDP
PSWSVLAGHS RTVSDSIKKL ITSMRDKAPG QLECETAIAA LNSCLRDLDQ ASLAAVSQQL
APREGISQEA LHTQMLTAVQ EISHLIEPLA NAARAEASQL GHKVSQMAQY FEPLTLAAVG
AASKTLSHPQ QMALLDQTKT LAESALQLLY TAKEAGGNPK QAAHTQEALE EAVQMMTEAV
EDLTTTLNEA ASAAGVVGGM VDSITQAINQ LDEGPMGEPE GSFVDYQTTM VRTAKAIAVT
VQEMVTKSNT SPEELGPLAN QLTSDYGRLA SEAKPAAVAA ENEEIGSHIK HRVQELGHGC
AALVTKAGAL QCSPSDAYTK KELIECARRV SEKVSHVLAA LQAGNRGTQA CITAASAVSG
IIADLDTTIM FATAGTLNRE GTETFADHRE GILKTAKVLV EDTKVLVQNA AGSQEKLAQA
AQSSVATITR LADVVKLGAA SLGSQHSSTQ VVLINAVKDV AKALGDLISA TKAAAGKVGD
DPAVWQLKNS AKVMVTNVTS LLKTVKAVED EATKGTRALE ATTEHIRQEL AVFCSPEPPA
KTSTPEDFIR MTKGITMATA KAVAAGNSCR QEDVIATANL SRRAIADMLR ACKEAAYHPE
VAPDVRLRAL HYGRECANGY LELLDHVLLT LQKPSPELKQ QLTGHSKRVA GSVTELIQAA
EAMKGTEWVD PEDPTVIAEN ELLGAAAAIE AAAKKLEQLK PRAKPKEADE SLNFEEQILE
AAKSIAAATS ALVKAASAAQ RELVAQGKVG AIPANALDDG QWSQGLISAA RMVAAATNNL
CEAANAAVQG HASQEKLISS AKQVAASTAQ LLVACKVKAD QDSEAMKRLQ AAGNAVKRAS
DNLVKAAQKA AAFEEQENET VVVKERMVGG IAQIIAAQEE MLRKERELEE ARKKLAQIRQ
QQYKFLPSEL RDEH
//
