ID   G1QX99_NOMLE            Unreviewed;       739 AA.
AC   G1QX99;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   Name=AP4B1 {ECO:0000313|Ensembl:ENSNLEP00000005570.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005570.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000005570.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000005570.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; ADFV01041494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003268051.1; XM_003268003.2.
DR   RefSeq; XP_004090030.1; XM_004089982.2.
DR   AlphaFoldDB; G1QX99; -.
DR   STRING; 61853.ENSNLEP00000005570; -.
DR   Ensembl; ENSNLET00000005858.2; ENSNLEP00000005570.1; ENSNLEG00000004580.3.
DR   GeneID; 100585947; -.
DR   KEGG; nle:100585947; -.
DR   CTD; 10717; -.
DR   eggNOG; KOG1061; Eukaryota.
DR   GeneTree; ENSGT00940000157025; -.
DR   HOGENOM; CLU_006320_4_2_1; -.
DR   InParanoid; G1QX99; -.
DR   OMA; FIQRPTR; -.
DR   OrthoDB; 648032at2759; -.
DR   TreeFam; TF354235; -.
DR   Proteomes; UP000001073; Chromosome 12.
DR   GO; GO:0030124; C:AP-4 adaptor complex; IEA:Ensembl.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0098541; C:cytoplasmic side of trans-Golgi network transport vesicle membrane; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0061938; P:protein localization to somatodendritic compartment; IEA:Ensembl.
DR   GO; GO:0006605; P:protein targeting; IEA:Ensembl.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR   PANTHER; PTHR11134:SF4; AP-4 COMPLEX SUBUNIT BETA-1; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR002291};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT   DOMAIN          620..732
FT                   /note="Beta-adaptin appendage C-terminal subdomain"
FT                   /evidence="ECO:0000259|SMART:SM01020"
SQ   SEQUENCE   739 AA;  83155 MW;  8B7D94527B64122C CRC64;
     MPYLGSEDVV KELKKALCNP HIQSDRLRYR NVIQRVIRYM TQGLDMSGVF MEMVKASATV
     DIVQKKLVYL YMCTYAPLKP DLALLAINTL CKDCSDPNPM VRGLALRSMC SLRMPGVQEY
     IQQPILNGLR DKASYVRRVA VLGCAKMHNL HGDSEVDGAL VNELYSLLRD QDPIVVVNCL
     RSLEEILKQE GGVVINKPIA HHLLNRMSKL DQWGQAEVLN FLLRYQPRSE EELFDILNLL
     DSFLKSSSPG VVMGATKLFL ILAKKFPHVQ TDVLVRVKGP LLAACSSESR ELCFVALCHV
     RQILHSLPGH FSSHYKKFFC SYSEPHYIKL QKVEVLCELV NDENVQQVLE ELRGYCTDVS
     ADFAQAAIFA IGGIARTYTD QCVQILTELL GLRQEHITTV VVQTFRDLVW LCPQCTEAVC
     QALPGCEENI QDSEGKQALI WLLGVHGERI PNAPYVLEDF VENVKSETFP AVKMELLTAL
     LRLFLSRPAE CQDVLGRLLY YCIEEEKDMA VRDRGLFYYR LLLVGIDEVK RILCSPKSDP
     TLGLLEDPAE RPVNSWASDF NTLVPVYGKA HWATISKCQG AECCGPELPK TSSFAASGPL
     IPEENKERVQ ELPDSGALML VPNHQLTADY FEKTWLSLKV AHQQVLPWRG EFHPDTLQMA
     LQVVNIQTIA MSRAGSRPWK AYLSAQDDTG CLFLTELLLE PENSEMQISV KQSEARTETL
     NSFISVLETV IGTIEEIKS
//