ID   G1QXC4_NOMLE            Unreviewed;       521 AA.
AC   G1QXC4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   Name=KPNA4 {ECO:0000313|Ensembl:ENSNLEP00000005595.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005595.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000005595.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000005595.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Functions in nuclear protein import.
CC       {ECO:0000256|PIRNR:PIRNR005673}.
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; ADFV01169701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01169702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01169703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003256433.1; XM_003256385.3.
DR   AlphaFoldDB; G1QXC4; -.
DR   SMR; G1QXC4; -.
DR   STRING; 61853.ENSNLEP00000005595; -.
DR   Ensembl; ENSNLET00000005883.2; ENSNLEP00000005595.1; ENSNLEG00000004571.2.
DR   GeneID; 100579775; -.
DR   KEGG; nle:100579775; -.
DR   CTD; 3840; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   GeneTree; ENSGT01050000244891; -.
DR   HOGENOM; CLU_018084_6_1_1; -.
DR   InParanoid; G1QXC4; -.
DR   OMA; IPRDGFN; -.
DR   OrthoDB; 916229at2759; -.
DR   TreeFam; TF101178; -.
DR   Proteomes; UP000001073; Chromosome 11.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005643; C:nuclear pore; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:Ensembl.
DR   GO; GO:0014046; P:dopamine secretion; IEA:Ensembl.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF7; IMPORTIN SUBUNIT ALPHA-3; 1.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   DOMAIN          1..58
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          114..158
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          157..184
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          284..322
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ   SEQUENCE   521 AA;  57887 MW;  D98BC45002C9F57E CRC64;
     MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS
     DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV
     HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA
     LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI
     QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV
     QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ
     VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL
     TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI
     IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F
//