ID G1QYC7_NOMLE Unreviewed; 415 AA.
AC G1QYC7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Procollagen C-endopeptidase enhancer 2 {ECO:0000313|Ensembl:ENSNLEP00000005948.1};
GN Name=PCOLCE2 {ECO:0000313|Ensembl:ENSNLEP00000005948.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005948.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005948.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; ADFV01028522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003265387.1; XM_003265339.3.
DR RefSeq; XP_012364048.1; XM_012508594.1.
DR AlphaFoldDB; G1QYC7; -.
DR STRING; 61853.ENSNLEP00000005948; -.
DR Ensembl; ENSNLET00000006257.2; ENSNLEP00000005948.1; ENSNLEG00000004883.2.
DR GeneID; 100599578; -.
DR KEGG; nle:100599578; -.
DR CTD; 26577; -.
DR eggNOG; ENOG502QRMG; Eukaryota.
DR GeneTree; ENSGT00940000157649; -.
DR HOGENOM; CLU_034096_0_0_1; -.
DR InParanoid; G1QYC7; -.
DR OMA; TMWRTCS; -.
DR OrthoDB; 5355450at2759; -.
DR TreeFam; TF316506; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0016504; F:peptidase activator activity; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR CDD; cd00041; CUB; 2.
DR CDD; cd03576; NTR_PCOLCE; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035814; NTR_PCOLCE.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR PANTHER; PTHR24251:SF31; PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 2; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00042; CUB; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059}; Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..415
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419166"
FT DOMAIN 33..144
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 154..268
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 297..415
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 154..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 415 AA; 45747 MW; 92C2DD3AFED14184 CRC64;
MRGANAWTPL CLLLAAATQL SRQQSPERPV FTCGGILTGE SGFIGSEGFP GVYPPNSKCT
WKITVPEGKV VVLNFRFIDL ESDNLCRYDF VDVYNGHANG QRIGRFCGTF RPGALVSSGN
KMMVQMISDA NTAGNGFMAM FSAAEPNERG DQYCGGRLDR PSGSFKTPNW PDRDYPAGVT
CVWHIVAPKN QLIELKFEKF DVERDNYCRY DYVAVFNGGE VNDARRIGKY CGDSPPAPIV
SERNELLIQF LSDLSLTADG FIGHYKFRPK KLPTTTAQPV TTTFPVTTGL KPTVALCQQK
CRRTGTLEGN YCSSDFVLAG TVITTITRDG SLHATVSIIN IYKEGNLAIQ QAGKNMSARL
TVVCKQCPLL RRGLNYIIMG QVGEDGRGKI MPNSFIMMFK TKNQKLLDAL KNKQC
//
