ID G1QYV0_NOMLE Unreviewed; 736 AA.
AC G1QYV0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A16 {ECO:0000313|Ensembl:ENSNLEP00000006121.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006121.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006121.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR EMBL; ADFV01051942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01051943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003269809.1; XM_003269761.2.
DR AlphaFoldDB; G1QYV0; -.
DR Ensembl; ENSNLET00000006436.2; ENSNLEP00000006121.1; ENSNLEG00000005039.2.
DR GeneID; 100596432; -.
DR KEGG; nle:100596432; -.
DR CTD; 28968; -.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000163283; -.
DR HOGENOM; CLU_006855_7_2_1; -.
DR InParanoid; G1QYV0; -.
DR OMA; YEKVQMT; -.
DR OrthoDB; 3084493at2759; -.
DR TreeFam; TF352709; -.
DR Proteomes; UP000001073; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:UniProt.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR CDD; cd11502; SLC6sbd_NTT5; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF324; ORPHAN SODIUM- AND CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTER NTT5; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 130..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 736 AA; 82011 MW; 671CADAA4EB89549 CRC64;
MKTETQPSTS SLADTSWSGT VIFDSVPGSQ TLEDKGPLTW SATSWTSEAQ VSAARVAEAQ
ARTSQPKQIS VLEASTASAL NQKPTYEKVQ MTEKKESEAL LARPFWSSKT AYILAQVGFS
MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP
WIGGVGYSSF MVCFILGLYF NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT
TPSIYFWYRQ ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL
PCFIIVGFFV RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT GIGLGSVASL
ASYMPQSNNC LSDAVLVSVI NLLTLLIFTS FNFSVLGFWA TVITHRCCER NAEILLKLIN
LGKLPPDAKP PVNLLDNPTS IYNAWFSGLP QHIKSMVLRE VTECNIETQF LKASEGPKFA
FLSFVEAMSF LPLSVFWSFI FFLMLLAMGL SSAIGIVQGI ITPLQDTFSF FRKHTKLLIV
EVFLLMFVCG LFFTRPSGSH FIRLLSDYWI VFPIIVIVVF ETMAVSWAYG ARRFLADLTI
LLGHPISPIC GWLWPRLCPV VLLILFVTMM VHLCMKPIAY MSWDSSTSKE VLRPYPPWAL
LLMITLFAIV ILPIPAYFVY CCIHRIPFRP KSGDGPMTAS ISLPLSHQLT PSKEVQKEEI
LQGDETKYPS TCHVTS
//
