ID G1R0C6_NOMLE Unreviewed; 588 AA.
AC G1R0C6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Basic helix-loop-helix ARNT like 2 {ECO:0000313|Ensembl:ENSNLEP00000006647.2};
GN Name=BMAL2 {ECO:0000313|Ensembl:ENSNLEP00000006647.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006647.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006647.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006647.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01029485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01029490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003265681.1; XM_003265633.3.
DR AlphaFoldDB; G1R0C6; -.
DR Ensembl; ENSNLET00000006980.3; ENSNLEP00000006647.2; ENSNLEG00000005463.3.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000160423; -.
DR HOGENOM; CLU_011864_2_2_1; -.
DR TreeFam; TF319983; -.
DR Proteomes; UP000001073; Chromosome 23.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11469; bHLH-PAS_ARNTL2_PASD9; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF48; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 59..112
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 130..195
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 330..379
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 23..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 65693 MW; 67D60CE5B7E4BD60 CRC64;
MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAVGS FSSHVTEFPQ KRKGSDSDPS
QEAHSQTEKR RRDKMNNLIE ELSAMIPQCN PMARKLDKLT VLRMAVQHLR SLKGLTNSYV
GNNYRPSFLQ DNELRHLILK TAEGFLFVVG CERGKILFVS KSVSKILNYD QASLTGQSLF
DFLHPKDVAK VKEQLSSFDI SPREKLIDAK TGLQVHSNFH TGRTRVYSGS RRSFFCRIKS
CKISVKEEHG RLPNSKKKEH RKFYTIHCTG YLRSWPPSIV GMEEERNSKK DNSNFTCLVA
IGRLQPYIVP QNSGEINVKP TEFITRFAVN GKFVYVDQRA TAILGYLPQE LLGTSCYEYF
HQDDHNNLTD KHKAVLQSKE KILTDSYKFR AKDGSFVTLK SQWFSFTNPW TKELEYIVSV
NTLVLGHSEP GEASFFPCSS QSSEESSRQS CVSVPGMSTG TVLGAGSIGT DIANEILDLQ
RLQSSSYLDD SNPTDLMKDT HTVNCRSMSN KELFPPSPSE MGELEATRQN RSTVAVHSHE
PLLSDGAQLD FDALCDNDDT AMAAFMNYLE AEGGLGDPGD FSDIQWTL
//
