ID G1R0I8_NOMLE Unreviewed; 1547 AA.
AC G1R0I8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Nuclear factor of activated T cells 5 {ECO:0000313|Ensembl:ENSNLEP00000006709.1};
GN Name=NFAT5 {ECO:0000313|Ensembl:ENSNLEP00000006709.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006709.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006709.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006709.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01013942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01013951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003262996.1; XM_003262948.2.
DR STRING; 61853.ENSNLEP00000006709; -.
DR Ensembl; ENSNLET00000007047.2; ENSNLEP00000006709.1; ENSNLEG00000005522.2.
DR GeneID; 100603294; -.
DR CTD; 10725; -.
DR eggNOG; ENOG502QSVE; Eukaryota.
DR GeneTree; ENSGT00940000155213; -.
DR HOGENOM; CLU_004396_0_0_1; -.
DR InParanoid; G1R0I8; -.
DR OMA; PYQNQVI; -.
DR OrthoDB; 5405363at2759; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1904996; P:positive regulation of leukocyte adhesion to vascular endothelial cell; IEA:Ensembl.
DR GO; GO:0062176; P:R-loop processing; IEA:Ensembl.
DR GO; GO:0070884; P:regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 282..461
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 58..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1547 AA; 167460 MW; C3A08067D8929091 CRC64;
MPSDFISLLS ADLDLESPKS LYSRDSLKLH PSQNFHRAGL LEESVYDLLP KELQLPPSRE
TSVASMSQTS GGEAGSPPPA VVAADASSAP SSSSMGGACS SFTTSSSPTI YSTSVTDSKA
MQVESCSSAV GVSNRGVSEK QLTSNTVQQH PSTPKRHTVL YISPPPEDLL DNSRMSCQDE
GCGLESEQSC SMWMEDSPSN FSNMSTSSYN DNTEVPRKSR KRNPKQRPGV KRRDCEESNM
DIFDADSAKA PHYVLSQLTT DNKGNSKAGN GTLENQKGTG VKKSPMLCGQ YPVKSEGKEL
KIVVQPETQH RARYLTEGSR GSVKDRTQQG FPTVKLEGHN EPVVLQVFVG NDSGRVKPHG
FYQACRVTGR NTTPCKEVDI EGTTVIEVGL DPSNNMTLAV DCVGILKLRN ADVEARIGIA
GSKKKSTRAR LVFRVNITRK DGSTLTLQTP SSPILCTQPA GVPEILKKSL HSCSVKGEEE
VFLIGKNFLK GTKVIFQENV SDENSWKSEA EIDMELFHQN HLIVKVPPYH DQHITLPVSV
GIYVVTNAGR SHDVQPFTYT PDPAAAGALN VNVKKEISSP ARPCSFEEAM KAMKTTGCNL
DKVNIISNAL MTPLIPSSMI KSEDVTPMEV TAEKRSSTIF KTTKSVGSTQ QTLENISNIA
GNGSFSSPSS SHLPSENEKQ QQIQPKAYNP ETLTTIQTQD ISQPGTFPAV SASSQLPNSD
ALLQQATQFQ TRETQSREVL QSDGTVVNLS QLTEASQQQQ SPLQEQAQTL QQQISSNIFP
SPSSVSQLQN TIQQLQAGSF TGSTAGGSSG SVDLVQQVLE AQQQLSSVLF SAPDGNENVQ
EQLSADIFQQ VSQIQSGVSP GMFSSTEPTV HTRPDNLLPG RAESVHPQSE NTLSNQQQQQ
QQQQVMESSA AMVMEMQQSI CQAAAQIQSE LFPSTASANG NLQQSPVYQQ TSHMMSALST
NEDMQMQCEL FSSPPAVSGN ETSTTTTQQV ATPGTTMFQT SSSGDGEETG TQAKQIQNSV
FQTMVQMQHS GDNQPQVNLF SSTKSMMSVQ NSGTQQQGNG LFQQGNEMMS LQSGNFLQQS
SHSQAQLFHP QNPIADAQNI SQETQGSLFH SPNPIVHSQT STTSSEQMQP PMFHSQSTIA
VLQGSSVPQD QQSTNIFLSQ SPMNNLQTNT VAQEAFFAAP NSISPLQSTS NTEQQAAFQQ
QAPISHIQTP MLSQEQAQPP QQGLFQPQVS LGSLPPNPMP QSQQGTMFQS QHSIVAMQSN
SPSQEQQQQQ QQQQQQQQQQ QQSILFSNQN TMATMASPKQ PPPNMIFNPN QNPMANQEQQ
NQSIFHQQSN MAPMNQEQQP MQFQSQSTVS SLQNPGPTQS ESSQTPLFHS SPQIQLVQGS
PSSQEQQVTL FLSPASMSAL QTSINQQDMQ QSPLYSPQNN MPGIQGATSS PQSQATLFHN
TAGGTMNQLQ NSPGSSQQTS GMFLFGIQNN CSQLLTSGPA TLPDQLMAIS QPGQPQNEGQ
PPVTTLLSQQ MPENSPLASS INTNQNIEKI DLLVSLQNQG NNLTGSF
//
