ID G1R1H8_NOMLE Unreviewed; 231 AA.
AC G1R1H8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cellular communication network factor 4 {ECO:0000313|Ensembl:ENSNLEP00000007050.3};
GN Name=CCN4 {ECO:0000313|Ensembl:ENSNLEP00000007050.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007050.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007050.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007050.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR EMBL; ADFV01169043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01169050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R1H8; -.
DR Ensembl; ENSNLET00000007400.2; ENSNLEP00000007050.3; ENSNLEG00000030189.1.
DR eggNOG; ENOG502QQQQ; Eukaryota.
DR GeneTree; ENSGT00940000158587; -.
DR HOGENOM; CLU_063247_2_0_1; -.
DR TreeFam; TF326070; -.
DR Proteomes; UP000001073; Chromosome 16.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR PANTHER; PTHR11348:SF4; CCN FAMILY MEMBER 4; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..231
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014167386"
FT DOMAIN 40..118
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 137..211
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 231 AA; 25409 MW; C3682E8AEA2E2A79 CRC64;
MRWFLPWTLA AVTAAAASSV LAMALSPAPT TMDFTPAPLE DTSSRPQFCK WPCECPPSPP
RCPLGVSLIT DGCECCKMCA QQLGDNCTEA AICDPHRGLY CDYSGDRPRY AIGVCALCNL
RPCDVDIRTL IKAGKKCLVV YHPEASMNFT LAGCVSTRSY QPKYCGVCMD NRCCIPYKSK
TINVSFQCPD GLGFSRQVLW INACFCNLNC RNPNDIFADL ESYPDFSEIS N
//
