ID G1R1K0_NOMLE Unreviewed; 303 AA.
AC G1R1K0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=SEC22 homolog C, vesicle trafficking protein {ECO:0000313|Ensembl:ENSNLEP00000007072.1};
GN Name=SEC22C {ECO:0000313|Ensembl:ENSNLEP00000007072.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007072.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007072.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007072.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in vesicle transport between the ER and the
CC Golgi complex. {ECO:0000256|ARBA:ARBA00003595}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
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DR EMBL; ADFV01172560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004087965.1; XM_004087917.1.
DR RefSeq; XP_012353577.1; XM_012498123.1.
DR AlphaFoldDB; G1R1K0; -.
DR STRING; 61853.ENSNLEP00000007072; -.
DR Ensembl; ENSNLET00000007424.2; ENSNLEP00000007072.1; ENSNLEG00000005827.2.
DR GeneID; 100586874; -.
DR KEGG; nle:100586874; -.
DR CTD; 9117; -.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000159338; -.
DR HOGENOM; CLU_054453_0_0_1; -.
DR InParanoid; G1R1K0; -.
DR OMA; QDRTNDC; -.
DR OrthoDB; 129635at2759; -.
DR TreeFam; TF105933; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14824; Longin; 1.
DR Gene3D; 3.30.450.50; Longin domain; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR043546; Sec22a/c.
DR PANTHER; PTHR46258; LONGIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46258:SF2; VESICLE-TRAFFICKING PROTEIN SEC22C; 1.
DR Pfam; PF13774; Longin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS50859; LONGIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..119
FT /note="Longin"
FT /evidence="ECO:0000259|PROSITE:PS50859"
SQ SEQUENCE 303 AA; 34250 MW; AE1F81DEC91B08C3 CRC64;
MSMIFFACVV RVRDGLPLSA STDFYHTQDF LEWRRRLKNL ALRLAQYPGR GSAEGCDFSI
HFSSFGDVAC MAICSCQCPA AMAFCFLETL WWEFTASYDT TCIGLASRPY AFLEFDSIIQ
KVKWHFNYVS SSQMESSLEK IQEELKLQPP AVLTLEDTDV ANGVMNGHAP MHLEPAPNFR
MEPVTALGIL SLILNIMCAA LNLIRGVHLA EHSLQVAHEE IGNILAFLVP FVACIFQCYL
YLFYSPARTM KVVLMLLFIC LGNVYLHGLR NLWQILFHIG VAFLSSYQIL TRQLQEKQSD
CGV
//
