ID G1R3M7_NOMLE Unreviewed; 364 AA.
AC G1R3M7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Zinc finger protein 589 {ECO:0000313|Ensembl:ENSNLEP00000007799.2};
GN Name=ZNF589 {ECO:0000313|Ensembl:ENSNLEP00000007799.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007799.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007799.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007799.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; ADFV01172938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R3M7; -.
DR Ensembl; ENSNLET00000008173.2; ENSNLEP00000007799.2; ENSNLEG00000006411.2.
DR GeneTree; ENSGT00940000164260; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; G1R3M7; -.
DR OMA; CHHEEYV; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR048414; PDRM9-like_Znf-C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF138; ZINC FINGER PROTEIN 589; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF21225; zf-C2H2_5; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 35..112
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 247..274
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 275..302
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 303..330
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 331..358
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 103..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 41429 MW; 0ED35DD5D082075C CRC64;
MWAPREQLLG WATEALPAKD SAWSWKEKPR YLGPVTFEDV AVLFTEAEWK RLSLEQRNLY
KEVMLENLRN LVLLAESKPE VHTCSSCPLA FGSQQFLSQD ELHNHPIPGF HAGNQFHPGN
PCPEDQPQSQ RPSDKNHRGA EAEDQRVEGG VRPLFWSTNE RGLVGFSSLF QRSPISSWGG
NRIFEIQFSP AQNASSEEVD RISKRAETPE FGAVRFGECA LAFNQKSNLF RQKAVTAEKS
SDKRQSQVCR ECGRGFSRKS QLIIQQRTHT GEKPYVCEEC GRGFIVESVL RNHLSAHSAE
KPYVCSHCGR GFSCKPYLMR HQRTHTREKS FMCTVCGRGF REKSELIKHQ IIHTGGKPYV
CRDC
//
