ID G1R3N0_NOMLE Unreviewed; 353 AA.
AC G1R3N0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Thrombopoietin {ECO:0000313|Ensembl:ENSNLEP00000007802.1};
GN Name=THPO {ECO:0000313|Ensembl:ENSNLEP00000007802.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007802.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007802.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007802.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC {ECO:0000256|ARBA:ARBA00005782}.
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DR EMBL; ADFV01170710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R3N0; -.
DR STRING; 61853.ENSNLEP00000007802; -.
DR Ensembl; ENSNLET00000008176.2; ENSNLEP00000007802.1; ENSNLEG00000006409.2.
DR eggNOG; ENOG502S9T0; Eukaryota.
DR GeneTree; ENSGT00390000006294; -.
DR HOGENOM; CLU_039844_0_0_1; -.
DR InParanoid; G1R3N0; -.
DR OMA; PILCARQ; -.
DR TreeFam; TF338084; -.
DR Proteomes; UP000001073; Chromosome 11.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR GO; GO:0035855; P:megakaryocyte development; IEA:Ensembl.
DR GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0097696; P:receptor signaling pathway via STAT; IEA:Ensembl.
DR GO; GO:0038163; P:thrombopoietin-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR019767; EPO/TPO_CS.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003978; Thrombopoietin.
DR PANTHER; PTHR10560; THROMBOPOIETIN; 1.
DR PANTHER; PTHR10560:SF0; THROMBOPOIETIN; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PRINTS; PR01485; THROMBOPTN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00817; EPO_TPO; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..353
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003419429"
FT REGION 258..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 37788 MW; D71134A4A9B5DAB5 CRC64;
MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVNPLPTPV
LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL
LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKV RFLMLVGGST LCVRRAPPTT
AVPSRTSLVL TLNELPNRTS GLLEKNFTAS ARTTGSGLLK RQQGFRAKIP GLLNQTSRSP
DQIPGYLNRI HELLNGTRGL FPGPSHRTLG APDISPGTSD TGSLPPNLQP GYSPSPTHLP
TGQYTLFPLP PTLPTPVVQL HPLLPDPSAP TPTPTSPLLN TSYTHSQNLS QEG
//