ID   G1R4E9_NOMLE            Unreviewed;       363 AA.
AC   G1R4E9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Adenosine deaminase {ECO:0000256|ARBA:ARBA00018099};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
DE   AltName: Full=Adenosine aminohydrolase {ECO:0000256|ARBA:ARBA00031852};
GN   Name=ADA {ECO:0000313|Ensembl:ENSNLEP00000008071.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008071.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000008071.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000008071.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+);
CC         Xref=Rhea:RHEA:28190, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17256, ChEBI:CHEBI:28938, ChEBI:CHEBI:28997; EC=3.5.4.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034443};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28191;
CC         Evidence={ECO:0000256|ARBA:ARBA00034443};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine + H(+) + H2O = inosine + NH4(+);
CC         Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=3.5.4.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001600};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409;
CC         Evidence={ECO:0000256|ARBA:ARBA00001600};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side
CC       {ECO:0000256|ARBA:ARBA00004296}. Cytoplasmic vesicle lumen
CC       {ECO:0000256|ARBA:ARBA00004321}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; ADFV01004425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01004426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01004427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003253658.1; XM_003253610.3.
DR   AlphaFoldDB; G1R4E9; -.
DR   Ensembl; ENSNLET00000008457.3; ENSNLEP00000008071.1; ENSNLEG00000006622.3.
DR   GeneID; 100596557; -.
DR   KEGG; nle:100596557; -.
DR   CTD; 100; -.
DR   eggNOG; KOG1097; Eukaryota.
DR   GeneTree; ENSGT00950000183113; -.
DR   HOGENOM; CLU_039228_0_1_1; -.
DR   OrthoDB; 36100at2759; -.
DR   TreeFam; TF314270; -.
DR   Proteomes; UP000001073; Chromosome 13.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   CDD; cd01320; ADA; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   HAMAP; MF_00540; A_deaminase; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR028893; A_deaminase.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide metabolism {ECO:0000256|ARBA:ARBA00023080};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          10..349
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   363 AA;  40735 MW;  0165FAB71EA90596 CRC64;
     MAQTPAFDKP KVELHVHLDG AIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD
     FLAKFDYYMP AIAGCREAIK RIAYEFVQMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA
     EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPEVVELCK KYQQQTVVAI
     DLAGDETIPG SSLLPGHVQA YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY
     HTLEDQALYD RLRQENMHFE ICPWSSYLTG AWKPDTEHAV VRLKNDQANY SLNTDDPLIF
     KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA YGMPPSASAG
     QNL
//