ID G1R5C7_NOMLE Unreviewed; 425 AA.
AC G1R5C7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=RNF123 {ECO:0000313|Ensembl:ENSNLEP00000008399.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008399.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000008399.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000008399.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR EMBL; ADFV01173171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R5C7; -.
DR Ensembl; ENSNLET00000008793.2; ENSNLEP00000008399.2; ENSNLEG00000006875.2.
DR eggNOG; KOG2242; Eukaryota.
DR eggNOG; KOG4692; Eukaryota.
DR GeneTree; ENSGT00940000155781; -.
DR TreeFam; TF313546; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16541; RING-HC_RNF123; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045129; RNF123/RSPRY1-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 366..404
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 425 AA; 47691 MW; 9032B5FE94A45463 CRC64;
MEHGYEETLT RLAAILAKHF ADTRIVGTDI RDSLMQALAS YVCYPHSLRA VERIPEEQRI
AMVRNLLAPY EQRPWAQTNW ILVRLWRGCG FGYRYTRLPH LLKTKLEDAN LPSLQKPCPS
TLLQQHMADL LQQGPDVAPS FLNSVLNQLN WAFSEFIGMI QEIQQAAERL ERNFVDSRQL
KVCATCFDLS VSLLRVLEMT ITLVPEIFLD WTRPTSEMLL RRLAQLLNQV LNRVTAERNL
FDRVVTLRLP GLESVDHYPI LVAVTGILVQ LLVRGPASER ERATSVLLAD PCFQLRSICY
LLGQPEPPAP GTALPAPDQK RFSLQSYADY ISADELAQVE QMLAHLTSAS AQAAAASLPT
SEEDLCPICY AHPISAVFQP CGHKSCKACI NQHLMNNRDC FFCKATIVSV EDWEKGANTS
TTSAA
//
