ID G1R6B7_NOMLE Unreviewed; 1725 AA.
AC G1R6B7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSNLEP00000008739.2};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSNLEP00000008739.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008739.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000008739.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000008739.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADFV01173455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000008739; -.
DR Ensembl; ENSNLET00000009156.3; ENSNLEP00000008739.2; ENSNLEG00000007161.3.
DR eggNOG; KOG1827; Eukaryota.
DR GeneTree; ENSGT00390000003017; -.
DR HOGENOM; CLU_001483_1_0_1; -.
DR InParanoid; G1R6B7; -.
DR OMA; WQFYETL; -.
DR TreeFam; TF106120; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 85..155
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 221..291
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 421..491
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 574..644
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 712..782
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 853..898
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 992..1110
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1192..1308
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1415..1483
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1415..1483
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 22..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1725 AA; 197031 MW; B828BE5863D9A5C3 CRC64;
MRRLAFRGAG CALVKLKKLD SMGSKRRRAT SPSSSVSGDF DDGHHSVSTP GPSRKRRRLS
NLPTVDPIAV CHELYNTIRD YKDEQGRLLC ELFIRAPKRR NQPDYYEVVS QPIDLMKIQQ
KLKMEEYDDV NLLTADFQLL FNNAKAYYKP DSPEYKAACK LWDLYLRTRN EFVQKGEADD
EDDDEDGQDN QGTVTEGSSP TYLKEILEQL LEAIVVATNP SGRLISELFQ KLPSKVQYPD
YYAIIKEPID LKTIAQRIQN GSYKSIHAMA KDIDLLAKNA KTYNEPGSQV FKDANSIKKI
FYMKKAEIEH HEMAKSSLRM RTPSNLAAAR LTGPSHSKGS LGEERNPTSK YYRNKRAVQG
GRLSAITMAL QYGSESEEDA ALAAARYEEG ESEAESITSF MDVSNPFYQL YDTVRSCRNN
QGQLIAEPFF HLPSKKKYPD YYQQIKMPIS LQQIRTKLKN QEYETLDHLE CDLNLMFENA
KRYNVPNSAI YKRVLKLQQV MQAKKKELAR RDDIEDGDSM ISSATSDTGS AKRKRNTHDS
EMLGLRRLSS KKNIRKQRMK ILFNVVLEAR EPGSGRRLCD LFMVKPSKKD YPDYYKIILE
PMDLKIIEHN IRNDKYAGEE GMIEDMKLMF RNARHYNEEG SQVYNDAHIL EKLLKEKRKE
LGPLPDDDDM ASPKLKLSRK SGISPKKSKY MTPMQQKLNE VYEAVKNYTD KRGRRLSAIF
LRLPSRSELP DYYLTIKKPM DMEKIRSHMM ANKYQDIDSM VEDFVMMFNN ACTYNEPESL
IYKDALVLHK VLLETRRDLE GDEDSHVPNV TLLIQELIHN LFVSVMSHQD DEGRCYSDSL
AEIPAVDPNF PNKPPLTFDI IRKNVENNRY RRLDLFQEHM FEVLERARRM NRTDSEIYED
AVELQQFFIK IRDELCKNGE ILLSPALSYT TKHLHNDVEK EKKEKLPKEI EEDKLKREEE
KREAEKSEDS SGTAGLSGLH RTYSQDCSFK NSMYHVGDYV YVEPAEANLQ PHIVCIERLW
EDSAGEKWLY GCWFYRPNET FHLATRKFLE KEVFKSDYYN KVPVSKILGK CVVMFVKEYF
KLCPENFRDE DVFVCESRYS AKTKSFKKIK LWTMPISSVR FVPRDVPLPV VRVASVFANA
DKGDDEKNTD NSEDSRAEDN FNLEKEKEDV PVEMSNGEPG CHYFEQLHYN DMWLKVGDCV
FIKSHGLVRP RVGRIEKVWV RDGAAYFYGP IFIHPEETEH EPTKMFYKKE VFLSNLEETC
PMTCILGKCA VLSFKDFLSC RPTEIPENDI LLCESRYNES DKQMKKFKGL KRFSLSAKVV
DDEIYYFRKP IVPQKEPSPL LEKKIQLLEA KFAELEGGDD DIEEMGEEDS EVIEPPSLPQ
LQTPLASELD LMPYTPPQST PKSAKGSAKK EGSKRKINMS GYILFSSEMR AVIKAQHPDY
SFGELSRLVG TEWRNLETAK KAEYEERAAK VAEQQERERA AQQQQPSASP RAGTPVGALM
GVVPPPTPMG MLNQQLTPVA GMMGGYPPGL PPLQGPVDGL VSMGSMQPLH PGGPPPHHLP
PGVPGLPGIP PPGVMNQGVA PMVGTPAPGG SPYGQQVGVL GPPGQQAPPP YPGPHPAGPP
VIQQPTTPMF VAPPPKTQRL LHSEAYLKYI EGLSAESNSI SKWDQTLAAR RRDVHLSKEQ
ESRLPSHWLK SKGAHTTMAD ALWRLRDLML RDTLNIRQAY NLENV
//
