ID G1R6Z8_NOMLE Unreviewed; 406 AA.
AC G1R6Z8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Transmembrane serine protease 4 {ECO:0000313|Ensembl:ENSNLEP00000008970.2};
GN Name=TMPRSS4 {ECO:0000313|Ensembl:ENSNLEP00000008970.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008970.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000008970.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000008970.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01056979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01056982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R6Z8; -.
DR Ensembl; ENSNLET00000009393.2; ENSNLEP00000008970.2; ENSNLEG00000007351.2.
DR GeneTree; ENSGT01020000230389; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252:SF8; ACROSIN; 1.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00202; SR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 174..403
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 406 AA; 45004 MW; 04B6E81BFC73F2EA CRC64;
QEQNKIKDQP LHRSFSFFLN FIKVILDKYY FLCGQPLHFI PRKQLCDGEL DCPLGEDEEH
CVKSFPEGPA VAVRLSKDRS TLQVLDPATG NWFSACFDNF TEALAETACR QMGYSSKPTF
RAVEIGPDQD LDVVEITENS QELHVWNSSG PCLSGSLVSL HCLACGESLK TPRVVGGEEA
SVDSWPWQVS IQYDKQHVCG GSILDPHWVL TAAHCFRKHT DVFNWKVRAG SDKLGSFPSL
AVAKIIIIEF NPMYPKDNDI ALMKLQFPLT FSGTVRPICL PFFDEELTPA TPLWIIGWGF
TKQSGGKMSD ILLQASVQVI DSTRCNADDA YQGEVTEKMM CAGIPEGGVD TCQGDSGGPL
MYQSDQWQVV GIVSWGYGCG GPSTPGVYTK VSAYLNWIYN VWKAEL
//
