ID G1R757_NOMLE Unreviewed; 955 AA.
AC G1R757;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIK4 {ECO:0000313|Ensembl:ENSNLEP00000009029.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000009029.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000009029.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000009029.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; ADFV01057259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R757; -.
DR STRING; 61853.ENSNLEP00000009029; -.
DR Ensembl; ENSNLET00000009456.2; ENSNLEP00000009029.2; ENSNLEG00000007406.3.
DR eggNOG; KOG1052; Eukaryota.
DR GeneTree; ENSGT00940000159111; -.
DR HOGENOM; CLU_007257_1_0_1; -.
DR InParanoid; G1R757; -.
DR OMA; RMMESRV; -.
DR TreeFam; TF334668; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IEA:Ensembl.
DR GO; GO:0032983; C:kainate selective glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0099507; F:ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13724; PBP2_iGluR_kainate_KA1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF171; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 546..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 623..645
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 804..828
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 416..785
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 426..490
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 861..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 107031 MW; 7E43FBDD1BAA2CF0 CRC64;
SPNPRQPQIF LPLVTVAVEY QLSPCGCLPT AAILDDPMEC SRGERLSITL AKNRINRAPE
RLGKAKVEVD IFELLRDSEY ETAETMCQIL PKGVVAVLGP SSSPASSSII SNICGEKEVP
HFKVAPEEFI KFQFQRFTTL NLHPSNTDIS VAVAGILNFF NCTTACLICA KAECLLNLEK
LLRQFLISKD TLSVRMLDDT RDPTPLLKEI RDDKTATIII HANASMSHTI LLKAAELGMV
SAYYTYIFTN LEFSLQRMDS LVDDRVNILG FSIFNQSHAF FQEFAQSLNQ SWQENCDHVP
FTGPALSSAL LFDAVYAVVT AVQELNRSQE IGVKPLSCGS AQIWQHGTSL MNYLRMVLPA
TLNSTAKAQR SNYALKILQF TRNGFRQIGQ WHVAEGLSMD SRLYASNISD TLFNTTLVVT
TILENPYLML KGNHQEMEGN DRYEGFCVDM LKELAEILRF NYKIRLVGDG VYGVPEANGT
WTGMVGELIA RKADLAVAGL TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD
PFSPGVWLFM LLAYLAVSCV LFLVARLTPY EWYSPHPCAQ GRCNLLVNQY SLGNSLWFPV
GGFMQQGSTI APRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMDV PIESVDDLAD
QTAIEYGTIH GGSSMTFFQN SRYQTYQRMW NYMYSKQPSV FVKSTEEGIA RVLNSNYAFL
LESTMNEYYR QRNCNLTQIG GLLDTKGYGI GMPVGSVFRD EFDLAILQLQ ENNRLEILKR
KWWEGGKCPK EEDHRAKGLG MENIGGIFVV LICGLIVAIF MAMLEFLWTL RHSEATEVSV
CQEMVTELRS IILCQDSIHP RRRRAGVPPP RPPIPEERRP RGTATLSNGK LCGAGEPDQL
AQRLAQEAAL VARGCTHIRV CPECRRFQGL RARPSPARSE ESLEWEKTTN SSEPE
//
