ID G1R7A9_NOMLE Unreviewed; 481 AA.
AC G1R7A9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Pseudouridine synthase 3 {ECO:0000313|Ensembl:ENSNLEP00000009081.1};
GN Name=PUS3 {ECO:0000313|Ensembl:ENSNLEP00000009081.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000009081.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000009081.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000009081.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; ADFV01057545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003253411.1; XM_003253363.1.
DR AlphaFoldDB; G1R7A9; -.
DR SMR; G1R7A9; -.
DR STRING; 61853.ENSNLEP00000009081; -.
DR Ensembl; ENSNLET00000009515.2; ENSNLEP00000009081.1; ENSNLEG00000007460.3.
DR GeneID; 100599496; -.
DR KEGG; nle:100599496; -.
DR CTD; 83480; -.
DR eggNOG; KOG2554; Eukaryota.
DR GeneTree; ENSGT00950000183160; -.
DR HOGENOM; CLU_014673_2_0_1; -.
DR InParanoid; G1R7A9; -.
DR OMA; YFGWEYN; -.
DR OrthoDB; 167554at2759; -.
DR TreeFam; TF314428; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:Ensembl.
DR CDD; cd02569; PseudoU_synth_ScPus3; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041707; Pus3-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 212..330
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 29..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 55572 MW; 9B49C2000DA5F928 CRC64;
MADNDTDRNQ TEKLLKRVQE LEQEVQRLKK EQAKNKEDSN IRENSSGAGK TKRAFDFSAH
GRRHVALRIA YMGWGYQGFA SQENTNNTIE EKLFEALTKT RLVESRQTSN YHRCGRTDKG
VSAFGQVISL DLRSQFPRGR ESEDFNVKEE ANAAAEEIRY THILNRVLPP DIRILAWAPV
EPSFSARFSC LERTYRYFFP RADLDIVTMD YAAQKYVGTH DFRNLCKMDV ANGVVNFQRT
ILSAQVQLVG QSPGEGRWQE PFQLCQFEVT GQAFLYHQVR CMMAILFLIG QGMEKPELID
ELLNIEKNPQ KPQYSMAVEF PLVLYDCKFE NVKWIYDQEA QEFNITHLQQ LWANHAVKTH
MLYSMLQGLD SVSVPCGIGP QMDGMTEWGN VKSSVIKQTS AFVEGVKMRT YKPLMDRPKC
QGLESRIQHF VRRGRIERPH LFHEEETKAK RDCNDTLEEE NTNLETPTKR VCVDTEIKSI
I
//
