ID G1R7R1_NOMLE Unreviewed; 930 AA.
AC G1R7R1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Seizure related 6 homolog like 2 {ECO:0000313|Ensembl:ENSNLEP00000009240.2};
GN Name=SEZ6L2 {ECO:0000313|Ensembl:ENSNLEP00000009240.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000009240.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000009240.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000009240.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; ADFV01133566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R7R1; -.
DR STRING; 61853.ENSNLEP00000009240; -.
DR Ensembl; ENSNLET00000009683.2; ENSNLEP00000009240.2; ENSNLEG00000007584.3.
DR eggNOG; ENOG502QS53; Eukaryota.
DR GeneTree; ENSGT00940000160492; -.
DR HOGENOM; CLU_011474_3_0_1; -.
DR InParanoid; G1R7R1; -.
DR OMA; DPGFQIR; -.
DR TreeFam; TF330037; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR GO; GO:0090036; P:regulation of protein kinase C signaling; IEA:Ensembl.
DR GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR PANTHER; PTHR45656:SF2; SEIZURE 6-LIKE PROTEIN 2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..930
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014184132"
FT TRANSMEM 864..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..292
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 294..353
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 355..465
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 468..531
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 533..644
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 648..707
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 709..772
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 775..836
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 93..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..144
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 355..382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 678..705
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 930 AA; 99922 MW; CB5E7C5D32190554 CRC64;
MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL
RRGPEMGYLP GSDPDPTLAT PPAGQTLTVP FLPRATEPGT GPLTTAVTPN GVRGAGPTAP
ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVAFL YPYYVPVLCN
NNISEGEGYV ESPDLGSPAS RTLGLLDCTY SIHVYPGYGI EIQVQTLNLS QEEELLVLAG
GGSPGLAPQL LANSSMLGEG QVLRSPTNRL LLHFQSPRVP RGGGFRIHYQ AYLLSCGFPP
RPTHGDVSVT DLHPGGTATF HCDSGYQLQG EETLICLNGT RPSWNGETPS CMASCGGTIH
NATLGRIVSP EPGGAVGPNL TCRWVIEAAE GRRLHLHFER VSLDEDNDRL MVRSGGSPLS
PVIYDSDMDD VPERGLISDA QSLYVELLSE TPANPLLLSL RFEAFEEDRC FAPFLAHGNV
TTTDPEYRPG ALATFSCLPG YALEPPGPPN AIECVDPTEP HWNDTEPACK AMCGGELSEP
AGVVLSPDWP QSYSPGQDCV WGLHVQEEKR ILLQVEILNV REGDMLTLFD GDGPSARVLA
QLRGPQPRRR LLSSGPDLTL QFQAPPGPPN PGLGQGFVLH FKEVPRNDTC PELPPPEWGW
RTASHGDLIR GTVLTYQCEP GYELLGSDIL TCQWDLSWSA APPACQKIMT CADPGEIANG
HRTASDAGFP VGSHVQYRCL PGYSLEGAAM LTCYSRDTGT PKWSDRVPKC ALKYEPCLNP
GVPENGYQTL YKHHYQAGES LRFFCYEGFE LIGEVTITCV PGHPSQWTSQ PPLCKVAYEE
LLDNRKLEVT QTTDPSRQLE GGNLALAILL PLGLVIVLGS GVYIYYTKLQ GKSLFGFSGS
HSYSPITVES DFSNPLYEAG VGTSPYEVSI
//
