ID G1R8A9_NOMLE Unreviewed; 191 AA.
AC G1R8A9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000009443.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000009443.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000009443.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
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DR EMBL; ADFV01133487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01133490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R8A9; -.
DR Ensembl; ENSNLET00000009897.2; ENSNLEP00000009443.2; ENSNLEG00000007771.2.
DR eggNOG; KOG3327; Eukaryota.
DR GeneTree; ENSGT00940000154030; -.
DR HOGENOM; CLU_049131_3_3_1; -.
DR OMA; YLANQSH; -.
DR TreeFam; TF324638; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 20..170
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 191 AA; 21592 MW; CC8864E81F4CCEB6 CRC64;
VISATWEADI MPLHSTLGHK RETLSTEIGK LLSSYLQKKS DVEDHSVHLL FSANRWEQVP
LIKEKLSQGV TLVVDRYAFS GVAFTGAKEN FSLDWCKQPD AGLPKPDLVL FLQLELADAA
KRGAFGHERY ENGAFQERAL QCFHQLMRDT TLNWKMVDAS KSIEAVHEDI RVLSEDAIRA
ATERPLGELW K
//
