ID G1R8I9_NOMLE Unreviewed; 450 AA.
AC G1R8I9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Protein-serine O-palmitoleoyltransferase porcupine {ECO:0000256|ARBA:ARBA00040371};
DE EC=2.3.1.250 {ECO:0000256|ARBA:ARBA00038867};
GN Name=PORCN {ECO:0000313|Ensembl:ENSNLEP00000009526.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000009526.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000009526.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000009526.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt
CC protein]-O-(9Z)-hexadecenoyl-L-serine + CoA; Xref=Rhea:RHEA:45336,
CC Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:85189;
CC EC=2.3.1.250; Evidence={ECO:0000256|ARBA:ARBA00035752};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC Porcupine subfamily. {ECO:0000256|ARBA:ARBA00038269}.
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DR EMBL; ADFV01097761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01097762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01097763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003276859.1; XM_003276811.2.
DR AlphaFoldDB; G1R8I9; -.
DR Ensembl; ENSNLET00000009983.2; ENSNLEP00000009526.2; ENSNLEG00000007822.3.
DR GeneID; 100594546; -.
DR KEGG; nle:100594546; -.
DR CTD; 64840; -.
DR eggNOG; KOG4312; Eukaryota.
DR GeneTree; ENSGT01030000234564; -.
DR HOGENOM; CLU_048745_0_0_1; -.
DR OrthoDB; 2957548at2759; -.
DR TreeFam; TF313724; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR004299; MBOAT_fam.
DR PANTHER; PTHR13906; PORCUPINE; 1.
DR PANTHER; PTHR13906:SF12; PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE; 1.
DR Pfam; PF03062; MBOAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 450 AA; 51020 MW; AD010CD2B5C2FD47 CRC64;
MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG
FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW
HKMRGAQMIV AMKAVSLGFD LDRGEVGTVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV
QGRPLSCRWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LDGDRLLRKW LRAYESAVSF
HFSNYFVGFL SEATATLAGA GFTEEKDHLE WDLTVSKPLN VELPRSMVEV VTSWNLPMSY
WLNNYVFKNA LRLGTFSAVL VTYAASALLH GFSFHLAAVL LSLAFITYVE HVLRKRLARI
LSACVLSKRC PPDCSHQHRL GLGVRALNLL FGALAIFHLA YLGSLFDVDV DDTTEEQGYG
MAYTVHKWSE LSWASHWVTF GCWIFYRLIG
//
