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Database: UniProt
Entry: G1RA88_NOMLE
LinkDB: G1RA88_NOMLE
Original site: G1RA88_NOMLE 
ID   G1RA88_NOMLE            Unreviewed;       579 AA.
AC   G1RA88;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   20-JUN-2018, entry version 43.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000010135};
GN   Name=SH2B2 {ECO:0000313|Ensembl:ENSNLEP00000010135};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010135};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000010135}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000010135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; ADFV01095964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01095965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01095966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01095967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSNLET00000010635; ENSNLEP00000010135; ENSNLEG00000008331.
DR   eggNOG; ENOG410IMWK; Eukaryota.
DR   eggNOG; ENOG41102PH; LUCA.
DR   GeneTree; ENSGT00530000063355; -.
DR   InParanoid; G1RA88; -.
DR   OMA; YDTEFFR; -.
DR   OrthoDB; EOG091G04RI; -.
DR   TreeFam; TF323184; -.
DR   Proteomes; UP000001073; Chromosome 17.
DR   GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR   GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR   GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR   GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
DR   GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IEA:Ensembl.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0050851; P:antigen receptor-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0001922; P:B-1 B cell homeostasis; IEA:Ensembl.
DR   GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR   GO; GO:0019222; P:regulation of metabolic process; IEA:Ensembl.
DR   CDD; cd10411; SH2_SH2B2; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR030520; SH2B2.
DR   InterPro; IPR035058; SH2B2_SH2.
DR   PANTHER; PTHR10872; PTHR10872; 2.
DR   PANTHER; PTHR10872:SF4; PTHR10872:SF4; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF109805; SSF109805; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN      165    278       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      364    462       SH2. {ECO:0000259|PROSITE:PS50001}.
SQ   SEQUENCE   579 AA;  62509 MW;  B906A79014E578A4 CRC64;
     MDPSYCPAHG FPSQDPLWPL SSQQWSSAHY SEPAAGGCDG TEAMNGAGPG PAAAAPVPVP
     VPDWRQFCEL HAQAAAVDFA HKFCRFLRDN PAYDTPDAGA SFSHHFAANF LDVFGEEVRR
     VLVAGPTTRG AAVRAEAMEP ESAESSALKA APYGHSRSSE DVSAHAATKG FSLRNMSLCV
     VDGVRDMWHR RKCRLLLRRA VAEERFRLEF FVPPKASRPK VSIPLSAIIE VRTTMPLEMP
     EKDNTFVLKV ENGAEYILET IDSLQKHSWV ADIQGCVDPG LRQENHLNLR DRGCSESRSH
     HCIPAWATEQ DSVSNKKIFR PGAVAHTCNP STLGGQGKED QLREQGAETD PEAEPELELS
     DYPWFHGTLS RVKAAQLVLA GGPRNHGLFV IRQSETRPGE YVLTFNFQGK AKHLRLSLNG
     HGQCHVQHLW FQSVLDMLRH FHTHPIPLES GGSADITLRS YVRAQGPPPE PGPTPPAAPA
     PPACWSDPPG QHYFSSLAAA ACPPASPSDA AGASSSSASS SSAASGPAPP RPVEGQLSAR
     SRSNSAERLL EAVAATAAEE SPEAALGRAR AVENQYSFY
//
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