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Database: UniProt
Entry: G1RAL1_NOMLE
LinkDB: G1RAL1_NOMLE
Original site: G1RAL1_NOMLE 
ID   G1RAL1_NOMLE            Unreviewed;      2615 AA.
AC   G1RAL1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSNLEP00000010258};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSNLEP00000010258};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010258};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000010258}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000010258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; ADFV01130918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01130927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000010258; -.
DR   Ensembl; ENSNLET00000010762; ENSNLEP00000010258; ENSNLEG00000008373.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000157078; -.
DR   InParanoid; G1RAL1; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000001073; Chromosome 1a.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2145   2170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2182   2200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2212   2232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2268   2293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2313   2335       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2442   2465       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      347    403       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    110       {ECO:0000256|SAM:Coils}.
FT   COILED     2573   2600       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2615 AA;  298043 MW;  B2387D4C0D5FC95B CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEVS RSTAGGCAHG NDIASLLSWT PHLQKTDSFV PRNSYVRLRH
     LCTNTWIQST NVPIDIEEER PIRLMLGTCP TKEDKEAFAI VSVPVSEIRD LDFANDASSM
     LASAVEKLNE GFISQNDRRF VIQLLEDLVF FVSDVPNNGQ NVLDIMVTKP NRERQKLMRE
     QNILKQIFGI LKAPFREKGG EGPLVRLEEL SDQKNAPYQH MFRLCYRVLR HSQEDYRKNQ
     EHIAKQFGMM QSQIGYDILA EDTITALLHN NRKLLEKHIT KTEVETFVSL VRKNREPRFL
     DYLSDLCVSN HIAIPVTQEL ICKCVLDPKN SDILIRTELR PVKEMAQSHE YLSIEYSDEE
     VWLTWTDKNN EHHEKSVRQL AQEARAGNAH DENVLSYYRY QLKLFARMCL DRQYLAIDEI
     SQQLGVDLIF LCMADEMLPF DLRASFCHLM LHVHVDRDPQ ELVTPVKFAR LWTEIPTAIT
     IKDYDSNLNA SRDDKKNKFA NTMEFVEDYL NNVVSEAVPF ANEEKNKLTF EVVSLAHNLI
     YFGFYSFSEL LRLTRTLLGI IDCVQGPPAM LQAYEDPGGK NVRRSIQGVG HMMSTMVLSR
     KQSVFSAPSL SAGASAAEPL DRSKFEENED IVVMETKLKI LEILQFILNV RLDYRISYLL
     SVFKKEFVEV FPMQDSGADG TAPAFDSTTA NMNLDRIGEQ AEAMFGVGKT SSMLEVDDEG
     GRMFLRVLIH LTMHDYAPLV SGALQLLFKH FSQRQEAMHT FKQVQLLISA QDVENYKVIK
     SELDRLRTMV EKSELWVDKK GSSKGEEVEA GAAKDKKEVR ALAHPPPLQI LERLNKMCGV
     GEQMRKKQQR LLKNMDAHKV MLDLLQIPYD KGDAKMMEIL RYTHQFLQKF CAGNPGNQAL
     LHKHLHLFLT PGLLEAETMQ HIFLNNYQLC SEISEPVLQH FVHLLATHGR HVQYLDFLHT
     VIKAEGKYVK KCQDMIMTEL TNAGDDVVVF YNDKASLAHL LDMMKAARDG VEDHSPLMYH
     ISLVDLLAAC AEGKNVYTEI KCTSLLPLED VVSVVTHEDC ITEVKMAYVN FVNHCYVDTE
     VEMKEIYTSN HIWTLFENFT LDMARVCSKR EKRVADPTLE KYVLSVVLDT INAFFSSPFS
     ENSTSLQTHQ TIVVQLLQST TRLLECPWLQ QQHKGSVEAC IRTLAMVAKG RAILLPMDLD
     AHISSMLSSG ASCAAAAQRN ASSYKATTRA FPRVTPTANQ WDYKNIIEKL QDIITALEER
     LKPLVQAELS VLVDVLHWPE LLFLEGSEAY QRCESGGFLS KLIQHTKDLM ESEEKLCIKV
     LRTLQQMLLK KTKYGDRGNQ LRKMLLQNYL QNRKSTSPGP RLVSNRGHQC RLDKEGATKL
     VCDLITSTKN EKIFPGEHRP GHPLLDGGNT EIQKSFHNLM MSDKKSERFF KVLHDRMKRA
     QQETKSTVAV NMNDLGSQPH EDREPVDPTT KGRLASFSIP GSSSRCSLGP SLHRGHEVSE
     RVQSNEMGTS VLIMQPILRF LQLLCENHNR DLQNFLRCQN NKTNYNLVCE TLQFLDIMCG
     STTGGLGLLG LYINEDNVGL VIQTLETLTE YCQGPCHENQ TCIVTHESNG IDIITALILN
     DISPLCKYRM DLVLQLKDNA SKLLLALMES RHDSENAERI LISLRPQELV DVIKKAYLQE
     EERENSEVSP REVGHNIYIL ALQLSRHNKQ LQHLLKPVKR IQEEEAEGIS SMLSLNNKQL
     SQMLKSSVPA QEEEEDPLAY YENHTSQIEI VRQDRSMEQI VFPVPGICQF LTEETKHRLF
     TTTEQDEQGS KVSDFFDQSS FLHNEMEWQR KLRSMPLIYW FSRRMTLWGS ISFNLAVFIN
     IIIAFFYPYM EGASTGVLDS PLISLLFWIL ICFSIAALFT KRYSIRPLIV ALILRSIYYL
     GIGPTLNILG ALNLTNKIVF VVSFVGNRGT FIRGYKAMVM DMEFLYHVGY ILTSVLGLFA
     HELFYSILLF DLIYREETLF NVIKSVTRNG RSILLTALLA LILVYLFSIV GFLFLKDDFI
     LEVDRLPNNH STASPLGMPH GAAAFVDTCS GDKMDCVSGV SVPEVLEEDG ELDSTERACD
     TLLMCIVTVM NHGLRNGGGV GDILRKPSKD ESLFPARVVY DLLFFFIVII IVLNLIFGVI
     IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKLEHNMW NYLYFIVLVR
     VKNKTDYTGP ESYVAQMIKN KNLDWFPRMR AMSLVSNEGE GEQNEIRILQ DKLNSTMKLV
     SHLTAQLNEL KEQMTEQRKR RQRLGFVDVQ NCMSR
//
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