ID G1RAS7_NOMLE Unreviewed; 560 AA.
AC G1RAS7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Lipase maturation factor {ECO:0000256|RuleBase:RU361229};
GN Name=LMF1 {ECO:0000313|Ensembl:ENSNLEP00000010324.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010324.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000010324.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000010324.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the maturation of specific proteins in the
CC endoplasmic reticulum. {ECO:0000256|RuleBase:RU361229}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU361229}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361229}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lipase maturation factor family.
CC {ECO:0000256|ARBA:ARBA00005512, ECO:0000256|RuleBase:RU361229}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361229}.
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DR EMBL; ADFV01048030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RAS7; -.
DR STRING; 61853.ENSNLEP00000010324; -.
DR Ensembl; ENSNLET00000010831.2; ENSNLEP00000010324.2; ENSNLEG00000008453.2.
DR eggNOG; ENOG502QT4H; Eukaryota.
DR GeneTree; ENSGT00530000063702; -.
DR HOGENOM; CLU_020557_2_0_1; -.
DR InParanoid; G1RAS7; -.
DR OMA; NFAWLNW; -.
DR TreeFam; TF314339; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051604; P:protein maturation; IEA:InterPro.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
DR InterPro; IPR009613; LMF.
DR PANTHER; PTHR14463; LIPASE MATURATION FACTOR; 1.
DR PANTHER; PTHR14463:SF10; LIPASE MATURATION FACTOR 1; 1.
DR Pfam; PF06762; LMF1; 2.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU361229};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361229};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361229};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361229}.
FT TRANSMEM 117..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 142..164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 289..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT TRANSMEM 359..380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361229"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 64129 MW; 8005C50954BBD75E CRC64;
MRPDSPTMAA PAESLRRRKT GYSDPEPESP PAPGRDPAGS PAHLHTGTSG LAFVYCEFVA
FLVAFHQNKQ LIGDRGLLPC RVFLKNFQQY FQDRTSWEVF SYMPTILWLM DWSDMNSNLD
LLALLGLGIS SFVLITGCAN MLLMAALWGL YMSLVNALLL WYFFGWESQL LETGFLGIFL
CPLWTLSRLP QHTPTSRIVL WGFRWLIFRI MLGAGLIKIR GDQCWRDLTC MDFHYETQPV
PNSVAYYLHH SPWWFHRVET LSNHFIELLV PFFLFLGRRA RILHGVLQIL FQAVLIVSGN
LSFLNWLTMV PSLACFDDAT LGFLFPSGPG SLKDQVLQMQ TEIRGAWPKP KFGSVVRRAA
NVSLGVLLAW LSVPVVFNLL SSRQVMNTHF NSLHIVNTYG AFGSITKERT EVILQGTASA
NASTPDTVWE DYEFKCKPGD PSRRPCLISP YHYRLDWLMW FAAFQTYEHN DWIIHLAGKL
LAGDAEALSL LAHNPFRGRP LPRWVRGEHY RYKFSRPGGR HAAEGKWWVR KRIGAYFPPL
SLEELRPYFR DRGWPLPQPL
//
