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Database: UniProt
Entry: G1RBK1_NOMLE
LinkDB: G1RBK1_NOMLE
Original site: G1RBK1_NOMLE 
ID   G1RBK1_NOMLE            Unreviewed;       780 AA.
AC   G1RBK1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   08-NOV-2023, entry version 68.
DE   RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A4 {ECO:0000313|Ensembl:ENSNLEP00000010598.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010598.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000010598.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000010598.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; ADFV01041965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01041966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01041967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01041968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01041969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01041970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01041971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003268184.1; XM_003268136.2.
DR   RefSeq; XP_012367587.1; XM_012512133.1.
DR   AlphaFoldDB; G1RBK1; -.
DR   STRING; 61853.ENSNLEP00000010598; -.
DR   Ensembl; ENSNLET00000011114.2; ENSNLEP00000010598.1; ENSNLEG00000008663.2.
DR   GeneID; 100583173; -.
DR   KEGG; nle:100583173; -.
DR   CTD; 5172; -.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   InParanoid; G1RBK1; -.
DR   OMA; WKQNKTD; -.
DR   OrthoDB; 1067648at2759; -.
DR   TreeFam; TF313784; -.
DR   Proteomes; UP000001073; Chromosome 13.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0015111; F:iodide transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        84..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        113..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        187..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        219..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        296..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        345..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        385..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        420..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        479..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          535..729
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   780 AA;  85760 MW;  921DE79665A4AE71 CRC64;
     MAAPGGRSEP PQLPEYSCSY VVSRPVYSEL AFQQQHERRL QERKTLRESL AKCCSCSRKR
     AFGVLKTLLP ILEWLPKYRV KEWLLSDIIS GVSTGLVATL QGMAYALLAA VPVGYGLYSA
     FFPILTYFIF GTSRHISVGP FPVVSLMVGS VVLSMAPDEH FLVSSSNGTV LNTTMIDTAA
     RDTARVLIAS ALTLLVGIIQ LIFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL
     NVSTKNYNGV LSIIYTLVEI FQNIGDTNLA DFTAGLLTIV VCMVVKELND RFRHKIPVPI
     PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPRGFLPPEL PPVSLFSEML AASFSIAVVA
     YAIAVSVGKV YATKYDYTID GNQEFIAFGI SNIFSGFFSC FVATTALSRT AVQESTGGKT
     QVAGIISAAI VMIAILALGK LLEPLQKSVL AAVVIANLKG MFMQVCDIPR LWRQNKIDAV
     IWVFTCIVSI ILGLDLGLLA GLIFGLLTVV LRVQFPSWNG LGSIPSTDIY KSTKNYKNIE
     EPQGVKILRF SSPIFYGNVD GFKKCIKSTV GFDAIRVYNK RLKALRKIQK LIKNGQLRAT
     KNGIISDAGS TNNAFEPDED IEDPEELDIP TKEIEIQVDW NSELPVKVNV PKVPIHSLVL
     DCGAISFLDV VGVRSLRVIV KEFQRIDVNV YFASLQDYVI EKLEQCGFFD DNIRKDTFFL
     TVHDAILYLQ NQVKSQEGQD SILETITLIQ DCKDTLELIE TELTEEELDV QDEAMRTLAS
//
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