ID   G1RBT3_NOMLE            Unreviewed;      1099 AA.
AC   G1RBT3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=Aminoadipate-semialdehyde dehydrogenase {ECO:0000313|Ensembl:ENSNLEP00000010682.1};
GN   Name=AASDH {ECO:0000313|Ensembl:ENSNLEP00000010682.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010682.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000010682.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000010682.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; ADFV01043664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01043665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01043666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01043667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003268446.1; XM_003268398.3.
DR   AlphaFoldDB; G1RBT3; -.
DR   STRING; 61853.ENSNLEP00000010682; -.
DR   Ensembl; ENSNLET00000011200.2; ENSNLEP00000010682.1; ENSNLEG00000008681.2.
DR   GeneID; 100580061; -.
DR   KEGG; nle:100580061; -.
DR   CTD; 132949; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   eggNOG; KOG4649; Eukaryota.
DR   GeneTree; ENSGT00440000033811; -.
DR   HOGENOM; CLU_010423_0_0_1; -.
DR   InParanoid; G1RBT3; -.
DR   OMA; NGNVICC; -.
DR   OrthoDB; 76882at2759; -.
DR   TreeFam; TF314245; -.
DR   Proteomes; UP000001073; Chromosome 9.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0043041; P:amino acid activation for nonribosomal peptide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0019482; P:beta-alanine metabolic process; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd17654; A_NRPS_acs4; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR048005; AASDH_AMP.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR002372; PQQ_repeat.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR44394; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   PANTHER; PTHR44394:SF1; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF13360; PQQ_2; 1.
DR   Pfam; PF13570; PQQ_3; 2.
DR   SMART; SM00564; PQQ; 6.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          554..631
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1099 AA;  122995 MW;  6625236B79BDFD76 CRC64;
     MTLQELVHKA ASCYMDRVAV CFDECNNQLP VYYTYKTVVN AASELSNFLL LHCDFQGIRE
     IGLYCQPGID LPSWILGILQ VPAAYVPIEP DSPPSLSTHF MKKCNLKYIL VEKKQINKFK
     SFHETLLNHD TFTVEHNDLV LFRLHWKNTE VNLMLNDGKE KYEKEKIKIS ISSEHVNEEK
     AEEHMDLRLK HCLAYVLHTS GTTGIPKIVR VPHKCIVPNI QHFRVLFDIT QEDVLFLASP
     LTFDPSVVEI FLALSSGASL LIVPTSVKLL PSKLASILFS HHRVTVLQAT PTLLRRFGSQ
     LIKSTVLSAT TSLRVLALGG EAFPSLTVLR SWRGEGNKTQ IFNVYGITEV SSWATIYRIP
     EKTLNSTLKC ELPVQLGFPL LGTVVEVRDT NGFTIQEGSG QVFLGGRNRV CFLDDEVTVP
     LGTMRATGDF VTVKDGEIFF LGRKDSQIKR HGKRLNIEFV QQVAEELQQV ESCAVTWYNQ
     EKLILFMVSK DASVKEYIFK ELQKYLPSHA VPDELVLIDS LPFTSHGKID VSELNKIYLN
     YINLKSENKL SGKEDLWEKL QYLWKSTLNL PEDLLRVPDE SLFLNSGGDS LKSIRLLSEI
     EKLVGTSVPG LLEIILSSSI LEIYNHILQT VFPDEDATFR KSCATKRKLS DINQEEASGT
     SLHQKAIMTF SCHNEINAFV VLSRGSQILS LNTTRFLTKL GHCSSACPSD SISQTNIQNL
     KGLNSPLLIG KSKDPSCVAK VSEEGKPVMG TQKMELHVRW RSDTGKCVDA SPLVVIPTFD
     KSSTTVYIGS HSHRMKAVDF YSGKVKWEQI LGDRIESSAC VSKCGNFIVV GCYNGLVYVL
     RSNSGEKYWM FTTEDAVKSS ATVDPTTGLI YIGSHDQHAY ALDIYRKKRV WKSKCGGTVF
     SSPCLNLIPH HLYFATLGGL LLAVNPATGN VIWKHSCGKP LFSSPRRCSQ YVCIGCVDGN
     LHCFTHFGEQ VWQFSTSGPI FSSPCTSPSE QKIFFGSHDC FIYCCNMKGH LQWKFETTSR
     VYATPFAFHK YNGSNEMLLA AASTDGKLWI LESQSGQLQS VYELPGEVFS SPVVLESMLI
     IGCRDNYVYC LDLLGGNQK
//