UniProt: G1RC83

Database: UniProt
Entry: G1RC83_NOMLE

LinkDB:  G1RC83_NOMLE 
Original site:  G1RC83_NOMLE

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Ontology (2)   
   GO (2)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (8)   
   EMBL (8)   
Protein domain (13)   
   InterPro (5)   
   Pfam (3)   
   PROSITE (3)   
   SMART (2)   
All databases (27)   

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ID   G1RC83_NOMLE            Unreviewed;       549 AA.
AC   G1RC83;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Ankyrin repeat and SOCS box containing 3 {ECO:0000313|Ensembl:ENSNLEP00000010832.2};
GN   Name=ASB3 {ECO:0000313|Ensembl:ENSNLEP00000010832.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010832.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000010832.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000010832.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC       {ECO:0000256|ARBA:ARBA00005949}.
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DR   EMBL; ADFV01009613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01009620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004090396.2; XM_004090348.2.
DR   AlphaFoldDB; G1RC83; -.
DR   STRING; 61853.ENSNLEP00000010832; -.
DR   Ensembl; ENSNLET00000011361.2; ENSNLEP00000010832.2; ENSNLEG00000008845.3.
DR   eggNOG; KOG0504; Eukaryota.
DR   GeneTree; ENSGT00940000159080; -.
DR   HOGENOM; CLU_000134_3_0_1; -.
DR   InParanoid; G1RC83; -.
DR   OMA; DCRSPMC; -.
DR   TreeFam; TF315127; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001073; Chromosome 14.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03722; SOCS_ASB3; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   Gene3D; 1.10.750.20; SOCS box; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037329; ASB3_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR   PANTHER; PTHR24173:SF74; UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 3.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 10.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 5.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50225; SOCS; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          40..72
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          109..141
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          142..174
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          176..208
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          209..241
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          242..274
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          472..535
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
SQ   SEQUENCE   549 AA;  61151 MW;  23F7D4F000CFABED CRC64;
     MAGRWQGKST EISVTPSHVL GPHEALRLVK QMDFTEAYVD TCSTVGLAAR EGNVKVLRKL
     LKKGRSVDVA DNRGWMPIHE AAYHNSVECL QMLINADSSE NYLKMKTFEG FCALHLAASQ
     GHWKILQILL EAGADPNATT LEETTPLFLA VENGQIDVLR LLLQHGANVN GSHSMCGWNS
     LHQASFQENA EIIKLLLIKG ANKECQDDFG ITPLFVAAQY GKLESLSILI SSGANVNCQA
     LDKATPLFIA AQEGHTKCVE LLLSSGADPD LYCNEDNWQL PIHAAAQMGH TKILDLLIPL
     TNRACDTGLN KVSPVYSAVF GGHEDCLELL LRNGYSPDAQ ACLVFGFSSP VCMAFQKDCE
     FFGIVNILLK YGAQINELHL AYCLKYEKFS IFRYFLRKGC SLGPWNHIYE FVNHAIKAQA
     KYKEWLPHLL VAGFDPLILL CNSWIDSVSI DTLIFTLEFT NWKTLAPAVE RMLSARASNA
     WILQQHIATV PSLTHLCRLE IRSSLKSERL RSDTYISQLP LPRSLHNYLL YEDVLRTYEV
     PELAAIQDG
//

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