ID G1RCW0_NOMLE Unreviewed; 295 AA.
AC G1RCW0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Signal transducing adaptor family member 1 {ECO:0000313|Ensembl:ENSNLEP00000011059.1};
GN Name=STAP1 {ECO:0000313|Ensembl:ENSNLEP00000011059.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011059.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011059.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01044039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01044041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003268470.1; XM_003268422.3.
DR RefSeq; XP_003268471.1; XM_003268423.1.
DR AlphaFoldDB; G1RCW0; -.
DR STRING; 61853.ENSNLEP00000011059; -.
DR Ensembl; ENSNLET00000011604.3; ENSNLEP00000011059.1; ENSNLEG00000009082.3.
DR eggNOG; ENOG502RZ9C; Eukaryota.
DR GeneTree; ENSGT00530000063841; -.
DR HOGENOM; CLU_043957_1_0_1; -.
DR InParanoid; G1RCW0; -.
DR OMA; PLYFQGY; -.
DR TreeFam; TF332087; -.
DR Proteomes; UP000001073; Chromosome 9.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005157; F:macrophage colony-stimulating factor receptor binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0030296; F:protein tyrosine kinase activator activity; IEA:Ensembl.
DR GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0010760; P:negative regulation of macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:1902227; P:negative regulation of macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
DR GO; GO:1904140; P:negative regulation of microglial cell migration; IEA:Ensembl.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:1900028; P:negative regulation of ruffle assembly; IEA:Ensembl.
DR GO; GO:0050861; P:positive regulation of B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1903980; P:positive regulation of microglial cell activation; IEA:Ensembl.
DR GO; GO:1904151; P:positive regulation of microglial cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IEA:Ensembl.
DR CDD; cd13268; PH_Brdg1; 1.
DR CDD; cd10403; SH2_STAP1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR039111; STAP1/STAP2.
DR InterPro; IPR035877; STAP1_SH2.
DR PANTHER; PTHR16186:SF10; SIGNAL-TRANSDUCING ADAPTOR PROTEIN 1; 1.
DR PANTHER; PTHR16186; SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 25..121
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 182..256
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 269..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 34321 MW; 195D40FE0412E450 CRC64;
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLVKRSGYR EYEHYWTELR GTTLFFYTDK
KSTIYVDKLD IIDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT
ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY
TVSRKEATEM LQKNPSSGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SIGQNYTIEL
EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPN MEGRNEKLKK NPHIA
//
