ID G1REA1_NOMLE Unreviewed; 649 AA.
AC G1REA1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011551.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011551.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011551.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01033296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01033297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1REA1; -.
DR Ensembl; ENSNLET00000012123.2; ENSNLEP00000011551.2; ENSNLEG00000009502.2.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000163508; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; G1REA1; -.
DR OMA; FQSYQYE; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF128; PROTOCADHERIN BETA-9; 1.
DR Pfam; PF00028; Cadherin; 2.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..649
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014120183"
FT TRANSMEM 538..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..303
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 304..413
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 428..528
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 649 AA; 71237 MW; F072E2E930671642 CRC64;
MKTRGFSFPR QRQVLFLFLF WGVSLAGSGF GRYSVTEETE RGSFVVNLAK DLGLAEGELA
ARGTRVVSDD NKQYLLLDSH TGNLLTNEKL DREKLCGPKE PCMLYFQILM DDPFQIYRAE
LRVRDINDHS PVFRDKEMVL KISENTAEGT AFRLERAQDP DGGLNGIQNY TISPNSFFHI
NISGSDEGTI YPELVLDKAL DREEQGELSL SARCTVLIKV LDTNDNPPEL IISSLSNSVI
ILLFLKPSVD NFYILMTEGA LDRESKAEYN ITITVTDLGT PRLKTEHSIT LQVSDVNDNA
PTFTQTSYTL FLRENNSPAL HIGSVSATDR DSGTNAQVTY SLLPPQDPHL PLPSLVSINA
DNGHLFALRS LDYEALQAFE FRVGATDRGS PALSSEALVR VLVLDANDNS PFVLYPLQNG
SAPCTELVPR AAEPGYLVTK VVAVDGDSGQ NAWLSYQLLK ATEPGLFGVW AHNGEVRTAR
LLSERDVAKH RLVVLVKDNG EPPRSATATL HVLLVDGFSQ PYLPLPETAP AQAQADSLTV
YLVVALASVS SLFLLSVLLF VAVRLCRRNR AASVGRCSVP EGPFPGHLVD VSGTGTLFQS
YQYEVCLTGG SETGEFKFLK PITPHLPPQS GGKEIEENST LRNSFGFNY
//
