ID G1REX4_NOMLE Unreviewed; 3531 AA.
AC G1REX4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=USP34 {ECO:0000313|Ensembl:ENSNLEP00000011774.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011774.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011774.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011774.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01009971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01009980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000012354.2; ENSNLEP00000011774.2; ENSNLEG00000009598.2.
DR eggNOG; KOG1866; Eukaryota.
DR GeneTree; ENSGT00940000158659; -.
DR HOGENOM; CLU_000109_0_0_1; -.
DR OMA; KLMYSLY; -.
DR TreeFam; TF323966; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021905; DUF3517.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF948; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34; 1.
DR Pfam; PF12030; DUF3517; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1879..2224
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 81..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3318..3428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3319..3358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3359..3394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3407..3422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3531 AA; 402536 MW; 1E08DD461B705587 CRC64;
SDVEGGDGLQ LRKEHTLKIF TYINSWTQRQ CLCCFKEYKH LEIFNQVVCA LINLVIAQVQ
VLRDQLCKHC TTINIDSTWQ DESNQGEEPL NIDRECNEGS TERQKSIEKK SNSTRICNLT
EEESSKSSDP FSLWSTDEKE KLLLCVAKIF QIQFPLYTAY KHNTHPTIED ISTQESNILG
AFCDMNDVEV PLHLLRYVCL FCGKNGLSLM KDCFEYGTPE TLPFLIAHAF ITVVSNIRIW
LHIPAVMQHI IPFRTYVIRY LCKLSDQELR QSAARNMADL MWSTVKEPLD TTLCFDKESL
DLAFKYFMSP TLTMRLAGLS QITNQLHTFN DVCNNESLVS DTETSIAKEL ADWLISNNVV
EHIFGPNLHI EIIKQCQVIL NFLAAEGRLS TQHIDCIWAA AQLKHCSRYI HDLFPSLIKN
LDPVPLRHLL NLVSALEPSV HTEQTLYLAS MLIKALWNNA LATKAQLSKQ SSFASLLNTN
IPIGNKKEEE ELRRTAPSPW SPAASPQSSD NSDTHQSGGS DIEMDEQLIN RTKHVQQRLS
DTEESMQGSS DETANSGEDG SSGPGSSSGH SDGSSNEVNS SHASQSAGSP GSEVQSEDIA
DIEALKEEDE DDDHGHNPPK SSCGTDLRNR KLESQAGICL GDSQGTSERN GTSSGTGKDL
VFNTESLPSV DNRMRMLDAC SHSEDPEHDI SGEMNATHIA QGSQESCITR TGDFLGETIG
NELFNCRQFI GPQHHHHHHH HHHHHDGHMV DDMLSADDVS CSSSQVSAKS EKNMADFDGE
ESGCEEELVQ INSHAELTSH LQQHLPNLAS IYHEHLSQGP VVHKHQFNSN AVTDINLDNV
CKKGNTLLWD IVQDEDAVNL SEGLINEAEK LLCSLVCWFT DRQIRMRFIE GCLENLGNNR
SVVISLRLLP KLFGTFQQFG SSYDTHWITM WAEKELNMMK LFFDNLVYYI QTVREGRQKH
ALYSHSAEVQ VRLQFLTCVF STLGSPDHFR LSLEQVDILW HCLVEDSECY DDALHWFLNQ
VRSKDQHAMG METYKHLFLE KMPQLKPETI SMTGLNLFQH LCNLARLATS AYDGCSNSEL
CGMDQFWGIA LRAQSGDVSR AAIQYINSYY INGKTGLEKE QEFISKCMES LMIASSSLEQ
ESHSSLMVIE RGLLMLKTHL EAFRRRFAYH LRQWQIEGTG ISSHLKALSD KQSLPLRVVC
QPAGLPDKMT IEMYPSDQVA DLRAEVTHWY ENLQKEQINQ QAQLQEFGQS NRKGEFPGGL
MGPVRMISSG HELTTDYDEK ALHELGFKDM QMVFVSLGAP RRERKGEGVQ LPASCLPPPQ
KDNIPMLLLL QEPHLTTLFD LLEMLASFKP PSGKVAVDDS ESLRCEELHL HAENLSRRVW
ELLMLLPTCP NMLMAFQNIS DEQSNDGFNW KELLKIKSAH KLLYALEIIE ALGKPNRRIR
RESTGSYSDL YPDSDDSSED QVENSKNSWS CKFVAAGGLQ QLLEIFNSGI LEPKEQESWT
VWQLDCLACL LKLICQFAVD PSDLDLAYHD VFAWSGIAES HRKRSWPGKS RKAAGDHAKG
LHIPRLTEVF LVLVQGTSLI QRLMSVAYTY DNLASRVLKA QSDHRSRHEV SHYSMWLLVS
WAHCCSLVKS SLADSDHLQD WLKKLTLLIP ETAVRHESCS GLYKLSLSGL DGGDSINRSF
LLLAASTLLK FLPDAQALKP IRIDDYEEEP ILKPGCKEYF WLLCKLVDNI HIKDASQTTL
LDLDALARHL ADCIRSREIL DHQDGNVEDD GLTGLLRLAT SVIKHKPPFK FSREGQEFLR
DIFNLLFLLP SLKDRQQPKC KSHSSRAAAY DLLVEMVKGS VENYRLIHNW VMAQHMQSHA
PYKWDYWPHE DVRAECRFVG LTNLGATCYL ASTIQQLYMI PEARQAVFTA KYSEDMKHKT
TLLELQKMFT YLMESECKAY NPRPFCKTYT MDKQPLNTGE QKDMTEFFTD LITKIEEMSP
ELKNTVKSLF GGVITNNVVS LDCEHVSQTA EEFYTVRCQV ADMKNIYESL DEVTIKDTLE
GDNMYTCSHC GKKVRAEKRA CFKKLPRILS FNTMRYTFNM VTMMKEKVNT HFSFPLRLDM
TPYTEDFLMG KSERKEGFKE VSDHSKDSES YEYDLIGVTV HTGTADGGHY YSFIRDIVNP
HAYKNNKWYL FNDAEVKPFD SAQLASECFG GEMTTKTYDS VTDKFMDFSF EKTHSAYMLF
YKRMEPEEEN GREYKFDVSS ELLEWIWHDN MQFLQDKNIF EHTYFGFMWQ LCSCIPSTLP
DPKAVSLMTA KLSTSFVLET FIHSKEKPTM LQWIELLTKQ FNNSQAACEW FLNRMADDDW
WPMQILIKCP NQIVRQMFQR LCIHVIQRLR PVHAHLYLQP GMEDGSDDMD ASVEDIGGRS
CVTRFVRTLL LIMEHGVKPH SKHLTEYFAF LYEFAKMGEE ESQFLLSLQA ISTMVHFYMG
TKGPENPQVE VLSEEEGEEE EEEEDILSLA EEKYRPAALE KMIALVALLV EQSRSERHLT
LSQTDMAALT GGKGFPFLFQ HIRDGINIRQ TCNLIFSLCR YNNRLAEHIV SMLFTSIAKL
TPEAANPFFK LLTMLMEFAG GPPGMPPFAS YILQRIWEVI EYNPSQCLDW LAVQTPRNKL
AHSWVLQNME NWVERFLLAH NYPRVRTSAA YLLVSLIPSN SFRQMFRSTR SLHIPTRDLP
LSPDTTVVLH QVYNVLLGLL SRAKLYVDAA VHGTTKLVPY FSFMTYCLIS KTEKLMFSTY
FMDLWNLFQP KLSEPAIATN HNKQALLSFW YNVCADCPEN IRLIVQNPVV TKNIAFNYIL
ADHDDQDVVL FNRGMLPAYY GILRLCCEQS PAFTRQLASH QNIQWAFKNL TPHASQYPGA
VEELFNLMQL FIAQRPDMRE EELEDIKQFK KTTISCYLRC LDGRSCWTTL ISAFRILLES
DEDRLLVIFN RGLILMTESF NTLHMMYHEA TACHVTGDLV ELLSIFLSVL KSTRPYLQRK
DVKQALIQWQ ERIEFAHKLL TLLNSYSPPE LRNACIDVLK ELVLLSPHDF LHTLVPFLQH
NHCTYHHSNI PMSLGPYFPC RENIKLIGGK SNIRPPRPEL NMCLLPTMVE TSKGKDDVYD
RMLLDYFFSY HQFIHLLCRV AINCEKFTET LVKLSVLVAY EGLPLHLALF PKLWTELCQT
QSAMSKNCIK LLCEDPVFAE YIKCILMDER TFLNNNIVYT FMTHFLLKVQ SQVFSEANCA
NLISTLITNL ISQYQNLQSD FSNRVEISKA SASLNGDLRA LALLLSVHTP KQLNPALIPT
LQELLSKCRS CLQQRNSLQE QEAKERKTKD DEGATPVKRR RVSSDEEHTV DSCISDMKTE
TREVLTPTST SDNETRDSSI IDPGTEQDLP SPENSSFKEY RMEVPSSFSE DMSNIRSQHA
EEQSSNGRYD DCKEFKDLHC SKDSTLAEEE SEFPSTSISA VLSDLADLRS CDGQALPSQD
PEVALSLSCG HSRGLFSHMR QHDILDTLCR TIESTIHVVT RISGKGNQAA S
//
