ID G1RF60_NOMLE Unreviewed; 704 AA.
AC G1RF60;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=TNF receptor associated protein 1 {ECO:0000313|Ensembl:ENSNLEP00000011860.1};
GN Name=TRAP1 {ECO:0000313|Ensembl:ENSNLEP00000011860.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011860.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011860.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011860.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; ADFV01048464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003269265.1; XM_003269217.3.
DR STRING; 61853.ENSNLEP00000011860; -.
DR Ensembl; ENSNLET00000012442.3; ENSNLEP00000011860.1; ENSNLEG00000009708.3.
DR eggNOG; KOG0019; Eukaryota.
DR GeneTree; ENSGT01020000230401; -.
DR HOGENOM; CLU_006684_3_1_1; -.
DR InParanoid; G1RF60; -.
DR OMA; DHTQQNE; -.
DR TreeFam; TF315234; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0071944; C:cell periphery; IEA:Ensembl.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:1901856; P:negative regulation of cellular respiration; IEA:Ensembl.
DR GO; GO:0009386; P:translational attenuation; IEA:Ensembl.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528:SF44; HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 108..261
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 704 AA; 79965 MW; 45798335AE80949C CRC64;
MARELRALLL WGRRLRPLLR APALAAVPGG KPILCPRRTT AQLGPRRNPA WSLQAGRLFS
TQTAEDKEEP LHSIISSTES VQGSTSKHEF QAETKKLLDI VARSLYSEKE VFIRELISNA
SDALEKLRHR LVSDGQALPE MEIHLQTDAE KGTITIQDTG IGMTQEELVS NLGTIARSGS
KAFLDALQNQ AEASSKIIGQ FGVGFYSAFM VADRVEVYSR SSAPGSPGYQ WLSDGSGVFE
IAEASGVRTG TKIIIHLKSD CKEFASEARV RDVVTKYSNF VSFPLYLNGR RMNTLQAVWM
MDPKDVGEWQ HEEFYRYIAQ AHDKPRYTLH YKTDAPLNIR SIFYVPDMXX XMFDVSRELG
PSVALYSRKV LIQTKATDVL PKWLRFTRGV VDSEDIPLNL SRELLQESAL IRKLRDVLQQ
RLIKFFIDQS KKDAEKYAKF FEDYGLFMRE GIVTATEQEV KEDIAKLLRY ESSALPAGQL
TSLSEYASRM RAGTRNIYYL CAPNRHLAEQ SPYYEAMKKK DTEVLFCFEQ FDELTLLHLR
EFDKKKLISV ETDIVVDHYK EEKFEDGSPA TECLSEKEME ELMAWMRNVL GSRVTNVKVT
LRLDTHPAMV TVLEMGAARH FLRMQQLAKT QEERAQLLQP TLEINPRHAL IKKLNQLRAS
EPGLAQLLVD QIYENAMIAA GLVDDPRAMV GRLNELLVKA LERH
//
